P1357: MILESTONE (MODIFYING ELANE GOLDBERG–HOGNES BOX TO INHIBIT EXPRESSION), A UNIVERSAL, SAFE AND EFFECTIVE CRISPR/CAS9N-MEDIATED GENOME EDITING STRATEGY FOR ELANE RELATED SEVERE CONGENITAL NEUTROPENIA

• Masoud Nasri,
• Malte Ulrich Ritter,
• Perihan Mir,
• Benjamin Dannenmann,
• Masako Monika Kaufmann,
• Yun Xu,
• Natalia Borbaran-Bravo,
• Maksim Klimiankou,
• Claudia Lengerke,
• Cornelia Zeidler,
• Toni Cathomen,
• Karl Welte,
• Julia Skokowa

Affiliations

Masoud Nasri

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany

Malte Ulrich Ritter

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany

Perihan Mir

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany

Benjamin Dannenmann

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany

Masako Monika Kaufmann

2 Institute for Transfusion Medicine and Gene Therapy, Medical Center, University of Freiburg, Freiburg, Germany

Yun Xu

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany

Natalia Borbaran-Bravo

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany

Maksim Klimiankou

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany

Claudia Lengerke

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany

Cornelia Zeidler

3 Hematology/ Oncology, SCNIR, Hannover Medical School, Hannover, Germany

Toni Cathomen

2 Institute for Transfusion Medicine and Gene Therapy, Medical Center, University of Freiburg, Freiburg, Germany

Karl Welte

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany

Julia Skokowa

1 University hospital tuebingen, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany, Tübingen, Germany