Nature Communications (Jan 2016)

IL-7 signalling represses Bcl-6 and the TFH gene program

  • Paul W. McDonald,
  • Kaitlin A. Read,
  • Chandra E. Baker,
  • Ashlyn E. Anderson,
  • Michael D. Powell,
  • André Ballesteros-Tato,
  • Kenneth J. Oestreich

DOI
https://doi.org/10.1038/ncomms10285
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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It remains incompletely understood how cytokines shape TH1 cell differentiation to central memory T (TCM) and follicular T helper (TFH) cells. Here the authors show that TH1 cells can co-initiate the expression of both TFH and TCM gene programs and that IL-7 signalling represses TFH-associated but not TCM-associated genes.