Nature Communications (Aug 2021)
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
- Daniel M. Kremer,
- Barbara S. Nelson,
- Lin Lin,
- Emily L. Yarosz,
- Christopher J. Halbrook,
- Samuel A. Kerk,
- Peter Sajjakulnukit,
- Amy Myers,
- Galloway Thurston,
- Sean W. Hou,
- Eileen S. Carpenter,
- Anthony C. Andren,
- Zeribe C. Nwosu,
- Nicholas Cusmano,
- Stephanie Wisner,
- Nneka E. Mbah,
- Mengrou Shan,
- Nupur K. Das,
- Brian Magnuson,
- Andrew C. Little,
- Milan R. Savani,
- Johanna Ramos,
- Tina Gao,
- Stephen A. Sastra,
- Carmine F. Palermo,
- Michael A. Badgley,
- Li Zhang,
- John M. Asara,
- Samuel K. McBrayer,
- Marina Pasca di Magliano,
- Howard C. Crawford,
- Yatrik M. Shah,
- Kenneth P. Olive,
- Costas A. Lyssiotis
Affiliations
- Daniel M. Kremer
- Department of Molecular & Integrative Physiology, University of Michigan
- Barbara S. Nelson
- Graduate Program in Cancer Biology, University of Michigan
- Lin Lin
- Department of Molecular & Integrative Physiology, University of Michigan
- Emily L. Yarosz
- Immunology Graduate Program, University of Michigan
- Christopher J. Halbrook
- Department of Molecular & Integrative Physiology, University of Michigan
- Samuel A. Kerk
- Graduate Program in Cancer Biology, University of Michigan
- Peter Sajjakulnukit
- Graduate Program in Cancer Biology, University of Michigan
- Amy Myers
- Department of Molecular & Integrative Physiology, University of Michigan
- Galloway Thurston
- Department of Molecular & Integrative Physiology, University of Michigan
- Sean W. Hou
- Department of Molecular & Integrative Physiology, University of Michigan
- Eileen S. Carpenter
- Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan
- Anthony C. Andren
- Department of Molecular & Integrative Physiology, University of Michigan
- Zeribe C. Nwosu
- Department of Molecular & Integrative Physiology, University of Michigan
- Nicholas Cusmano
- Department of Molecular & Integrative Physiology, University of Michigan
- Stephanie Wisner
- Department of Molecular & Integrative Physiology, University of Michigan
- Nneka E. Mbah
- Department of Molecular & Integrative Physiology, University of Michigan
- Mengrou Shan
- Department of Molecular & Integrative Physiology, University of Michigan
- Nupur K. Das
- Department of Molecular & Integrative Physiology, University of Michigan
- Brian Magnuson
- Department of Biostatistics, School of Public Health, University of Michigan
- Andrew C. Little
- Rogel Cancer Center, University of Michigan
- Milan R. Savani
- Medical Scientist Training Program, University of Texas Southwestern Medical Center
- Johanna Ramos
- Department of Molecular & Integrative Physiology, University of Michigan
- Tina Gao
- Department of Molecular & Integrative Physiology, University of Michigan
- Stephen A. Sastra
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Carmine F. Palermo
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Michael A. Badgley
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Li Zhang
- Department of Molecular & Integrative Physiology, University of Michigan
- John M. Asara
- Division of Signal Transduction and Mass Spectrometry Core, Beth Israel Deaconess Medical Center
- Samuel K. McBrayer
- Children’s Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center
- Marina Pasca di Magliano
- Rogel Cancer Center, University of Michigan
- Howard C. Crawford
- Department of Molecular & Integrative Physiology, University of Michigan
- Yatrik M. Shah
- Department of Molecular & Integrative Physiology, University of Michigan
- Kenneth P. Olive
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Costas A. Lyssiotis
- Department of Molecular & Integrative Physiology, University of Michigan
- DOI
- https://doi.org/10.1038/s41467-021-24859-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.
