Nature Communications (Apr 2017)

EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes

  • Judith Kreher,
  • Kristina Kovač,
  • Karim Bouazoune,
  • Igor Mačinković,
  • Anna Luise Ernst,
  • Erik Engelen,
  • Roman Pahl,
  • Florian Finkernagel,
  • Magdalena Murawska,
  • Ikram Ullah,
  • Alexander Brehm

DOI
https://doi.org/10.1038/ncomms14806
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

InDrosophila, ecdysone-regulated genes are bound by a heterodimer of ecdysone receptor (EcR) and Ultraspiracle. Here, the authors provide evidence of a non-canonical complex containing EcR and the nucleosome remodeller dMi-2 that limits transcription of ecdysone-regulated genes.