Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria

Christopher D. Ma; Denise Faust; Herbert L. Bonkovsky

Molecular Genetics and Metabolism Reports (Mar 2023)

Idiosyncratic drug-induced liver injury caused by givosiran in a patient with acute intermittent porphyria

Christopher D. Ma,
Denise Faust,
Herbert L. Bonkovsky

Affiliations

Christopher D. Ma: Department of Internal Medicine, Section on Gastroenterology and Hepatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Denise Faust: Department of Internal Medicine, Section on Gastroenterology and Hepatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Herbert L. Bonkovsky: Corresponding author at: Department of Internal Medicine, Section on Gastroenterology and Hepatology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.; Department of Internal Medicine, Section on Gastroenterology and Hepatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Journal volume & issue: Vol. 34
p. 100946

Abstract

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A 39-year-old woman with biochemically and clinically active acute intermittent porphyria (AIP) developed moderately severe liver injury after receiving her second dose of givosiran. Serologic evaluation ruled out hepatitis caused by viral, autoimmune, or other metabolic etiologies. The updated Roussel Uclaf Causality Assessment Method (RUCAM) score was 8 and the Revised Electronic Causality Assessment Method (RECAM) score for givosiran was 9. Results of liver tests returned to normal after givosiran was discontinued, and she has not received any more givosiran.

Published in Molecular Genetics and Metabolism Reports

ISSN: 2214-4269 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: http://www.journals.elsevier.com/molecular-genetics-and-metabolism-reports/

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