Gapdh Shows Altered Gene Expression in Alcohol Models

Taseva T.; Koycheva Y.; Simeonova S.; Nikolova E.; Krasteva M.

doi:10.2478/amb-2022-0014

Acta Medica Bulgarica (Jun 2022)

Gapdh Shows Altered Gene Expression in Alcohol Models

Taseva T.,
Koycheva Y.,
Simeonova S.,
Nikolova E.,
Krasteva M.

Affiliations

Taseva T.: Institute of plant physiology and genetics, Laboratory of genome dynamics and stability, Bulgarian Academy of Sciences – Sofia, Bulgaria
Koycheva Y.: Institute of plant physiology and genetics, Laboratory of genome dynamics and stability, Bulgarian Academy of Sciences – Sofia, Bulgaria
Simeonova S.: Institute of plant physiology and genetics, Laboratory of genome dynamics and stability, Bulgarian Academy of Sciences – Sofia, Bulgaria
Nikolova E.: Medical University of Sofia, Department of Medical Chemistry and Biochemistry – Sofia, Bulgaria
Krasteva M.: Institute of plant physiology and genetics, Laboratory of genome dynamics and stability, Bulgarian Academy of Sciences – Sofia, Bulgaria

DOI: https://doi.org/10.2478/amb-2022-0014
Journal volume & issue: Vol. 49, no. 2
pp. 16 – 21

Abstract

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Background and objectives. Though glyceraldehyde-3-phosphate dehydrogenase (Gapdh) is one of the most commonly used housekeeping genes for comparison of gene expression data, studies have revealed that Gapdh expression is not constant at different developmental stages, and is modulated by many factors including ethanol. In view of this, in the present study, we investigated the effect of ethanol on Gapdh stability and expression levels in different model systems.

Published in Acta Medica Bulgarica

ISSN: 0324-1750 (Print); 2719-5384 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine
Website: https://sciendo.com/journal/AMB

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