Potential vestibular pathway impairment in children with recurrent vertigo: An investigation through air-conducted sound and galvanic vestibular stimulation-triggered vestibular evoked myogenic potentials

Xiayu Sun; Xiayu Sun; Xiayu Sun; Dekun Gao; Dekun Gao; Dekun Gao; Jiali Shen; Jiali Shen; Jiali Shen; Qi Zhu; Lu Wang; Lu Wang; Lu Wang; Xiaobao Ma; Xiaobao Ma; Xiaobao Ma; Wei Wang; Wei Wang; Wei Wang; Xiangping Chen; Xiangping Chen; Xiangping Chen; Qing Zhang; Qing Zhang; Qing Zhang; Yulian Jin; Yulian Jin; Yulian Jin; Jianyong Chen; Jianyong Chen; Jianyong Chen; Jun Yang; Jun Yang; Jun Yang

doi:10.3389/fneur.2022.997205

Frontiers in Neurology (Oct 2022)

Potential vestibular pathway impairment in children with recurrent vertigo: An investigation through air-conducted sound and galvanic vestibular stimulation-triggered vestibular evoked myogenic potentials

Xiayu Sun,
Xiayu Sun,
Xiayu Sun,
Dekun Gao,
Dekun Gao,
Dekun Gao,
Jiali Shen,
Jiali Shen,
Jiali Shen,
Qi Zhu,
Lu Wang,
Lu Wang,
Lu Wang,
Xiaobao Ma,
Xiaobao Ma,
Xiaobao Ma,
Wei Wang,
Wei Wang,
Wei Wang,
Xiangping Chen,
Xiangping Chen,
Xiangping Chen,
Qing Zhang,
Qing Zhang,
Qing Zhang,
Yulian Jin,
Yulian Jin,
Yulian Jin,
Jianyong Chen,
Jianyong Chen,
Jianyong Chen,
Jun Yang,
Jun Yang,
Jun Yang

Affiliations

Xiayu Sun: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Xiayu Sun: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Xiayu Sun: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Dekun Gao: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Dekun Gao: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Dekun Gao: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Jiali Shen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jiali Shen: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jiali Shen: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Qi Zhu: Department of Otorhinolaryngology-Head & Neck Surgery, Yuyao People's Hospital, Yuyao, China
Lu Wang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Lu Wang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Lu Wang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Xiaobao Ma: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Xiaobao Ma: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Xiaobao Ma: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Wei Wang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Wei Wang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Wei Wang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Xiangping Chen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Xiangping Chen: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Xiangping Chen: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Qing Zhang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Qing Zhang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Qing Zhang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Yulian Jin: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Yulian Jin: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Yulian Jin: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Jianyong Chen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jianyong Chen: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jianyong Chen: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Jun Yang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jun Yang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jun Yang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China

DOI: https://doi.org/10.3389/fneur.2022.997205
Journal volume & issue: Vol. 13

Abstract

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ObjectiveThis study aims to investigate the potential vestibular pathway impairment through vestibular evoked myogenic potentials (VEMPs) and to explore the pathophysiological significance of these instrument-based findings in children with recurrent vertigo.Materials and methodsThe clinical data of 21 children (mean age 4.67 ± 1.39 years) diagnosed as RVC who met the inclusion criteria of the Bárány Society and 29 healthy children (mean age 4.83 ± 1.34 years) enrolled as the control group from February 2021 to December 2021 were collected and analyzed retrospectively. All the subjects underwent both cervical VEMP (cVEMP) and ocular VEMP (oVEMP) triggered by air-conducted sound (ACS) and galvanic vestibular stimulation (GVS), respectively. The elicit rate, latency, and amplitude asymmetry ratio (AAR) of ACS-cVEMP, ACS-oVEMP, GVS-cVEMP, and GVS-oVEMP were analyzed.Results(1) The elicit rates of ACS-cVEMP and ACS-oVEMP were similar in the two groups (P > 0.05), as well as GVS-cVEMP and GVS-oVEMP (P > 0.05). (2) P1 and N1 latencies of ACS-cVEMP and GVS-cVEMP in the RVC group were longer than those in the control group (P < 0.05). (3) The N1 latency of ACS-oVEMP in the RVC group was shorter than that in the control group (P < 0.05), while there was no significant difference in the P1 latency of ACS-oVEMP (P > 0.05). The N1 and P1 latencies of GVS-oVEMP were not significantly different (P > 0.05). (4) There was no statistical difference in the AAR of ACS-cVEMP and GVS-cVEMP. Although there was an increased AAR of ACS-oVEMP in the RVC group (P < 0.05), the AAR was within the normal range. However, no statistical difference was found in the AAR of GVS-oVEMP in the two groups (P > 0.05).ConclusionThe latencies of ACS-cVEMP and GVS-cVEMP in children with recurrent vertigo were significantly prolonged compared with those in healthy children, and there was no difference in elicit rates of ACS-cVEMP and GVS-cVEMP, suggesting that there might be potential impairment in the inferior vestibular nerve and the subsequent nerve conduction pathway in RVC.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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