Influence of circulating nesfatin-1, GSH and SOD on insulin secretion in the development of T2DM

Kangkang Huang; Kangkang Huang; Yunlai Liang; Kun Wang; Jiahui Wu; Jiahui Wu; Huidan Luo; Huidan Luo; Bin Yi; Bin Yi

doi:10.3389/fpubh.2022.882686

Frontiers in Public Health (Aug 2022)

Influence of circulating nesfatin-1, GSH and SOD on insulin secretion in the development of T2DM

Kangkang Huang,
Kangkang Huang,
Yunlai Liang,
Kun Wang,
Jiahui Wu,
Jiahui Wu,
Huidan Luo,
Huidan Luo,
Bin Yi,
Bin Yi

Affiliations

Kangkang Huang: Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China
Kangkang Huang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Yunlai Liang: Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China
Kun Wang: Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China
Jiahui Wu: Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China
Jiahui Wu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Huidan Luo: Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China
Huidan Luo: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Bin Yi: Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China
Bin Yi: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fpubh.2022.882686
Journal volume & issue: Vol. 10

Abstract

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AimsTo evaluate the correlation of nesfatin-1, GSH and SOD levels with β-cell insulin secretion and their influence on insulin secretion in the development of type 2 diabetes mellitus (T2DM).Materials and methods75 patients with T2DM, 67 with prediabetes and 37 heathy participants were recruited in this study. Serum levels of nesfatin-1, GSH and SOD were quantified and statistically analyzed.ResultsThe levels of nesfatin-1, GSH and SOD in T2DM were significantly decreased (P < 0.001) compared to either in prediabetes or in healthy control, and significant reduction of these biomarkers was also observed in prediabetes when compared to the control (P < 0.001). Circulating nesfatin-1, GSH and SOD were not only strongly correlated with β-cell insulin secretion, but also exerted remarkable influence on the secretion.ConclusionSerum nesfatin-1, GSH and SOD are important factors involving insulin secretion in the development of T2DM, which may help provide new ideas for forthcoming investigations on the roles of these factors in pathogenesis of T2DM, as well as for active prediction and prevention of prediabetes before it develops into overt T2DM.

Published in Frontiers in Public Health

ISSN: 2296-2565 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Public aspects of medicine
Website: https://www.frontiersin.org/journals/public-health

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