Cluster analysis of allergen reagents in atopic dermatitis patients according to the specific IgE results in ALEX2 Allergy Explorer test

Abstract

The aim of this study is the Cluster analysis of specific IgE results in ALEX2 Allergy Explorer test in atopic dermatitis (AD) patients. The complete dermatological and allergological examination including the examination of the sensitisation to allergen reagents with ALEX2 Allergy Explorer testing was performed. The cluster analysis (silhouette value) was processed for results of specific IgE and for clinical parameters. Altogether 100 atopic dermatitis patients were examined – 48 men, 52 women, the average age 40.9 years. Although the distribution of specific IgE results corresponds to the division into protein families, the links between specific IgE to allergens reagents in clusters are weak. Our results strongly point towards cross-reactivity for crustacean-allergic patients to desert locust, house cricket and stable flies. Combining the results of specific IgE for the basic allergen reagents together with the results of specific IgE for less common allergens can help in the estimating of allergic reactions.

Keywords

• cluster analysis – silhouette
• atopic dermatitis
• molecular components
• multiplex alex2 allergy explorer testing
• protein families
• biochemical structure