New Voltammetric Study of MgCl2 as Alternative Contrast Media in MRI Molecular Imaging

Abstract

Gadolinium compounds have been used as a common contrast media in MRI technique; however, they have oxidation-reduction current peaks in blood medium. To propose a solution for this problem, the alternative of contrast media in magnetic resonance imaging (MRI) was studied by electrochemical method using cyclic voltammetric technique. Magnesium compound was chosen such as MgCl2 which has a good electrochemical properties especially in blood medium. It was found that Mg (Ⅱ) ions in blood medium acted as an antioxidative reagent. The results of this study focused on the effect of magnesium chloride ions in normal saline, KCl solution and blood medium in presence with ascorbic acid (AA) and folic acid (FA) and understanding the redox current peaks of Mg (Ⅱ) ions in these conditions. We obtained good results by using MgCl2 solution as an alternative contrast medium in MRI technique instead of using of gadolinium compounds.

Keywords

• mri contrast media
• cyclic voltammetry (cv)
• mgcl2
• ascorbic acid (aa)
• folic acid (fa)