Morphological Alterations in Immunocompetent Organs of Animals in Dynamics of Vaccinal Process Caused by Live Plague Vaccine with Immunomodulators

Abstract

Arabinoganactane isolated from Siberian larch (Larix sibirica) and its iron and cobalt nanobiocomposites were selected as immunomodulators to elucidate the possibility of intensification of specific immunity against plague. Comparative morphometric analysis of immune system organs of white mice inoculated with live plague vaccine (LPV) and its combination with immunomodulators was performed. Experimental data indicate that arabinogalactane and its nanobiocomposites used in combination with LPV increase immunocytopoetic function of immune system organs to larger extent than LPV.

Keywords

• live plague vaccine
• immunity
• immunomodulators
• immunocompetent organs