Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Jan 2017)
Consensus guidelines for lumbar puncture in patients with neurological diseases
- Sebastiaan Engelborghs,
- Ellis Niemantsverdriet,
- Hanne Struyfs,
- Kaj Blennow,
- Raf Brouns,
- Manuel Comabella,
- Irena Dujmovic,
- Wiesje van derFlier,
- Lutz Frölich,
- Daniela Galimberti,
- Sharmilee Gnanapavan,
- Bernhard Hemmer,
- Erik Hoff,
- Jakub Hort,
- Ellen Iacobaeus,
- Martin Ingelsson,
- Frank Jan de Jong,
- Michael Jonsson,
- Michael Khalil,
- Jens Kuhle,
- Alberto Lleó,
- Alexandre deMendonça,
- José Luis Molinuevo,
- Guy Nagels,
- Claire Paquet,
- Lucilla Parnetti,
- Gerwin Roks,
- Pedro Rosa‐Neto,
- Philip Scheltens,
- Constance Skårsgard,
- Erik Stomrud,
- Hayrettin Tumani,
- Pieter Jelle Visser,
- Anders Wallin,
- Bengt Winblad,
- Henrik Zetterberg,
- Flora Duits,
- Charlotte E. Teunissen
Affiliations
- Sebastiaan Engelborghs
- Reference Center for Biological Markers of Dementia (BIODEM)Department of Biomedical SciencesInstitute Born‐Bunge, University of AntwerpAntwerpBelgium
- Ellis Niemantsverdriet
- Reference Center for Biological Markers of Dementia (BIODEM)Department of Biomedical SciencesInstitute Born‐Bunge, University of AntwerpAntwerpBelgium
- Hanne Struyfs
- Reference Center for Biological Markers of Dementia (BIODEM)Department of Biomedical SciencesInstitute Born‐Bunge, University of AntwerpAntwerpBelgium
- Kaj Blennow
- Clinical Neurochemistry LaboratoryDepartment of Psychiatry and NeurochemistryInstitute of Neuroscience and PhysiologyThe Sahlgrenska AcademyUniversity of GothenburgMölndalSweden
- Raf Brouns
- Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel)Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB)BrusselsBelgium
- Manuel Comabella
- Servei de Neurologia‐Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat)Institut de Receca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de BarcelonaBarcelonaSpain
- Irena Dujmovic
- Clinic of Neurology, Clinical Centre of Serbia, Department of Neurology, Faculty of MedicineUniversity of Belgrade School of MedicineBelgradeSerbia
- Wiesje van derFlier
- Alzheimer center and Department of Neurology, Neuroscience Campus AmsterdamVU University Medical CenterAmsterdamThe Netherlands
- Lutz Frölich
- Department of Geriatric PsychiatryCentral Institute of Mental HealthMedical FacultyMannheim/Heidelberg UniversityMannheimGermany
- Daniela Galimberti
- Neurology Unit, Department of Pathophysiology and TransplantationUniversity of Milan, Fondazione Ca’ Granda, IRCCS Ospedale PoliclinicoMilanItaly
- Sharmilee Gnanapavan
- Department of Neuroscience and TraumaBlizard Institute, Queen Mary University of LondonLondonUnited Kingdom
- Bernhard Hemmer
- Department of NeurologyTechnische Universität MünchenMunichGermany
- Erik Hoff
- Department of NeurologyAtrium Medisch Centrum ParkstadHeerlenThe Netherlands
- Jakub Hort
- Memory Disorders Clinic, Department of Neurology, 2nd Faculty of MedicineCharles University in Prague and Motol University HospitalPragueCzech Republic
- Ellen Iacobaeus
- Department of Clinical NeuroscienceKarolinska Institute, Karolinska University HospitalStockholmSweden
- Martin Ingelsson
- Department of Public Health and Caring SciencesUppsala UniversityUppsalaSweden
- Frank Jan de Jong
- Department of NeurologyErasmus Medical CenterRotterdamThe Netherlands
- Michael Jonsson
- Memory Clinic, Department of NeuropsychiatrySahlgrenska University Hospital, Institute of Neuroscience and PhysiologySahlgrenska AcademyUniversity of GothenburgMölndalSweden
- Michael Khalil
- Department of NeurologyMedical University GrazGrazAustria
- Jens Kuhle
- Department of NeurologyUniversity Hospital BaselBaselSwitzerland
- Alberto Lleó
- Memory Unit, Department of NeurologyHospital de la Santa Creu i Sant PauBarcelonaSpain
- Alexandre deMendonça
- Laboratory of NeurosciencesDepartment of Molecular Medicine and Faculty of MedicineUniversity of LisbonLisbonPortugal
- José Luis Molinuevo
- Alzheimer's disease and other cognitive disorders unit, Neurology ServiceHospital Clinic i Universitari, IDIBAPSBarcelonaSpain
- Guy Nagels
- Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel)Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB)BrusselsBelgium
- Claire Paquet
- Research Memory Center Lariboisière Hospital University Paris Diderot INSERMU942ParisFrance
- Lucilla Parnetti
- Section of Neurology, Centre for Memory Disturbances, Department of MedicineUniversity of PerugiaPerugiaItaly
- Gerwin Roks
- Department of NeurologySt Elisabeth ZiekenhuisTilburgThe Netherlands
- Pedro Rosa‐Neto
- Departments of Neurology & Neurosurgery and Psychiatry, McGill Centre for Studies in AgingDouglas Hospital Research Center, McGill UniversityMontrealCanada
- Philip Scheltens
- Alzheimer center and Department of Neurology, Neuroscience Campus AmsterdamVU University Medical CenterAmsterdamThe Netherlands
- Constance Skårsgard
- Department of GeriatricsKalmar County HospitalKalmarSweden
- Erik Stomrud
- Clinical Memory Research Unit, Department of Clinical SciencesLund UniversityLundSweden
- Hayrettin Tumani
- CSF Laboratory and Multiple Sclerosis Outpatient UnitDepartment of NeurologyUniversity of UlmUlmGermany
- Pieter Jelle Visser
- Neurochemistry Laboratory and BiobankDepartment of Clinical Chemistry, Neuroscience Campus AmsterdamVU University Medical CenterAmsterdamThe Netherlands
- Anders Wallin
- Memory Clinic, Department of NeuropsychiatrySahlgrenska University Hospital, Institute of Neuroscience and PhysiologySahlgrenska AcademyUniversity of GothenburgMölndalSweden
- Bengt Winblad
- Karolinska InstitutetDepartment of Neurobiology, Care Sciences and Society (NVS)Center for Alzheimer ResearchDivision for NeurogeriatricsHuddingeSweden
- Henrik Zetterberg
- Clinical Neurochemistry LaboratoryDepartment of Psychiatry and NeurochemistryInstitute of Neuroscience and PhysiologyThe Sahlgrenska AcademyUniversity of GothenburgMölndalSweden
- Flora Duits
- Alzheimer center and Department of Neurology, Neuroscience Campus AmsterdamVU University Medical CenterAmsterdamThe Netherlands
- Charlotte E. Teunissen
- Neurochemistry Laboratory and BiobankDepartment of Clinical Chemistry, Neuroscience Campus AmsterdamVU University Medical CenterAmsterdamThe Netherlands
- DOI
- https://doi.org/10.1016/j.dadm.2017.04.007
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 111 – 126
Abstract
Abstract Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post‐LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II‐2), (2) systematic literature review on LP needle characteristics and post‐LP complications (evidence level II‐2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient‐related and procedure‐related risk factors that can influence the development of post‐LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.
Keywords
