Journal of Comparative Effectiveness Research (Jun 2023)

Comparative efficacy of therapies for relapsing multiple sclerosis: a systematic review and network meta-analysis

  • Imtiaz A Samjoo,
  • Christopher Drudge,
  • Sarah Walsh,
  • Santosh Tiwari,
  • Roisin Brennan,
  • Ibolya Boer,
  • Dieter A Haring,
  • Luisa Klotz,
  • Nicholas Adlard,
  • Judit Banhazi

DOI
https://doi.org/10.57264/cer-2023-0016
Journal volume & issue
Vol. 12, no. 7

Abstract

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Aim: To assess the relative efficacy of disease-modifying therapies (DMTs) for relapsing multiple sclerosis (RMS) including newer therapies (ozanimod, ponesimod, ublituximab) using network meta-analysis (NMA). Materials & methods: Bayesian NMAs for annualised relapse rate (ARR) and time to 3-month and 6- month confirmed disability progression (3mCDP and 6mCDP) were conducted. Results: For each outcome, the three most efficacious treatments versus placebo were monoclonal antibody (mAb) therapies: alemtuzumab, ofatumumab, and ublituximab for ARR; alemtuzumab, ocrelizumab, and ofatumumab for 3mCDP; and alemtuzumab, natalizumab, and either ocrelizumab or ofatumumab (depending on the CDP definition used for included ofatumumab trials) for 6mCDP. Conclusion: The most efficacious DMTs for RMS were mAb therapies. Of the newer therapies, only ublituximab ranked among the three most efficacious treatments (for ARR).

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