Nature Communications (Jan 2020)
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
- Filipa C. Simões,
- Thomas J. Cahill,
- Amy Kenyon,
- Daria Gavriouchkina,
- Joaquim M. Vieira,
- Xin Sun,
- Daniela Pezzolla,
- Christophe Ravaud,
- Eva Masmanian,
- Michael Weinberger,
- Sarah Mayes,
- Madeleine E. Lemieux,
- Damien N. Barnette,
- Mala Gunadasa-Rohling,
- Ruth M. Williams,
- David R. Greaves,
- Le A. Trinh,
- Scott E. Fraser,
- Sarah L. Dallas,
- Robin P. Choudhury,
- Tatjana Sauka-Spengler,
- Paul R. Riley
Affiliations
- Filipa C. Simões
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Thomas J. Cahill
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Amy Kenyon
- Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Daria Gavriouchkina
- Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Joaquim M. Vieira
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Xin Sun
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Daniela Pezzolla
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Christophe Ravaud
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Eva Masmanian
- Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Michael Weinberger
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Sarah Mayes
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Madeleine E. Lemieux
- Bioinfo
- Damien N. Barnette
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Mala Gunadasa-Rohling
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Ruth M. Williams
- Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- David R. Greaves
- Sir William Dunn School of Pathology, University of Oxford
- Le A. Trinh
- Translational Imaging Centre, University of Southern California
- Scott E. Fraser
- Translational Imaging Centre, University of Southern California
- Sarah L. Dallas
- School of Dentistry, University of Missouri-Kansas City
- Robin P. Choudhury
- Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
- Tatjana Sauka-Spengler
- Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Paul R. Riley
- Department of Physiology, Anatomy and Genetics, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-019-14263-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Macrophages mediate the fibrotic response after a heart attack by extracellular matrix turnover and cardiac fibroblasts activation. Here the authors identify an evolutionarily-conserved function of macrophages that contributes directly to the forming post-injury scar through cell-autonomous deposition of collagen.
