Nature Communications (Apr 2021)

Comprehensive omic characterization of breast cancer in Mexican-Hispanic women

  • Sandra L. Romero-Cordoba,
  • Ivan Salido-Guadarrama,
  • Rosa Rebollar-Vega,
  • Veronica Bautista-Piña,
  • Carlos Dominguez-Reyes,
  • Alberto Tenorio-Torres,
  • Felipe Villegas-Carlos,
  • Juan C. Fernández-López,
  • Laura Uribe-Figueroa,
  • Luis Alfaro-Ruiz,
  • Alfredo Hidalgo-Miranda

DOI
https://doi.org/10.1038/s41467-021-22478-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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Cancers in different populations have been shown to be genetically distinct. Here, the authors sequence breast cancers from Mexican-Hispanic patients and find that these patients have a higher percentage of Akt1 mutations compared to Caucasian and Asian populations, suggesting these are clinically actionable.