Cell-Free DNA: Hope and Potential Application in Cancer

Yan-yan Yan; Yan-yan Yan; Qiao-ru Guo; Qiao-ru Guo; Feng-hua Wang; Rameshwar Adhikari; Zhuang-yan Zhu; Hai-yan Zhang; Wen-min Zhou; Hua Yu; Jing-quan Li; Jian-ye Zhang; Jian-ye Zhang; Jian-ye Zhang

doi:10.3389/fcell.2021.639233

Frontiers in Cell and Developmental Biology (Feb 2021)

Cell-Free DNA: Hope and Potential Application in Cancer

Yan-yan Yan,
Yan-yan Yan,
Qiao-ru Guo,
Qiao-ru Guo,
Feng-hua Wang,
Rameshwar Adhikari,
Zhuang-yan Zhu,
Hai-yan Zhang,
Wen-min Zhou,
Hua Yu,
Jing-quan Li,
Jian-ye Zhang,
Jian-ye Zhang,
Jian-ye Zhang

Affiliations

Yan-yan Yan: School of Medicine, Shanxi Datong University, Datong, China
Yan-yan Yan: Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Qiao-ru Guo: Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Qiao-ru Guo: The First Affiliated Hospital, Hainan Medical University, Haikou, China
Feng-hua Wang: Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China
Rameshwar Adhikari: Research Centre for Applied Science and Technology, Tribhuvan University, Kirtipur, Nepal
Zhuang-yan Zhu: School of Medicine, Shanxi Datong University, Datong, China
Hai-yan Zhang: School of Medicine, Shanxi Datong University, Datong, China
Wen-min Zhou: Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Hua Yu: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, Avenida da Universidade, Taipa, China
Jing-quan Li: The First Affiliated Hospital, Hainan Medical University, Haikou, China
Jian-ye Zhang: School of Medicine, Shanxi Datong University, Datong, China
Jian-ye Zhang: Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Jian-ye Zhang: The First Affiliated Hospital, Hainan Medical University, Haikou, China

DOI: https://doi.org/10.3389/fcell.2021.639233
Journal volume & issue: Vol. 9

Abstract

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Cell-free DNA (cfDNA) is easily accessible in peripheral blood and can be used as biomarkers for cancer diagnostics, prognostics, and therapeutics. The applications of cfDNA in various areas of cancer management are attracting attention. In this review article, we discuss the potential relevance of using cfDNA analysis in clinical oncology, particularly in cancer screening, early diagnosis, therapeutic evaluation, monitoring disease progression; and determining disease prognosis.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

About the journal

Abstract

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