Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles

Isabel Fernández de Castro Martin; Guillaume Fournier; Martin Sachse; Javier Pizarro-Cerda; Cristina Risco; Nadia Naffakh

doi:10.1038/s41467-017-01557-6

Nature Communications (Nov 2017)

Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles

Isabel Fernández de Castro Martin,
Guillaume Fournier,
Martin Sachse,
Javier Pizarro-Cerda,
Cristina Risco,
Nadia Naffakh

Affiliations

Isabel Fernández de Castro Martin: Centro Nacional de Biotecnologia, CNB-CSIC, Department of Macromolecular Structures, Cell Structure Lab
Guillaume Fournier: Département de Virologie, Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN
Martin Sachse: Center for Innovation and Technological Research, Ultrastructural Bio-imaging, Institut Pasteur
Javier Pizarro-Cerda: Département de Biologie Cellulaire et Infection, Institut Pasteur, Unité des Interactions Bactéries-Cellules
Cristina Risco: Centro Nacional de Biotecnologia, CNB-CSIC, Department of Macromolecular Structures, Cell Structure Lab
Nadia Naffakh: Département de Virologie, Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN

DOI: https://doi.org/10.1038/s41467-017-01557-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Transport of neo-synthesized influenza A virus viral ribonucleoproteins (vRNPs) from the nucleus to the plasma membrane involves Rab 11 but the mechanism is unclear. Here the authors show that vRNPs are transported through a modified Rab11-positive endoplasmic reticulum and Rab11-dependent vesicles.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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