RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells

Seika Hashimoto-Hill; Leon Friesen; Sungtae Park; Suji Im; Mark H. Kaplan; Chang H. Kim

doi:10.1038/s41467-018-06341-8

Nature Communications (Sep 2018)

RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells

Seika Hashimoto-Hill,
Leon Friesen,
Sungtae Park,
Suji Im,
Mark H. Kaplan,
Chang H. Kim

Affiliations

Seika Hashimoto-Hill: Department of Comparative Pathobiology, Purdue University
Leon Friesen: Department of Comparative Pathobiology, Purdue University
Sungtae Park: Department of Comparative Pathobiology, Purdue University
Suji Im: Department of Comparative Pathobiology, Purdue University
Mark H. Kaplan: Department of Pediatrics, Indiana University School of Medicine
Chang H. Kim: Laboratory of Immunology and Hematopoiesis, Mary H. Weiser Food Allergy Center, University of Michigan Medical School

DOI: https://doi.org/10.1038/s41467-018-06341-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin. Here the authors show that these immune cells are regulated by retinoic acid receptor alpha (RARα) via simultaneous induction of LC-promoting Runx3 and repression of LC-inhibiting C/EBPβ.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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