Frontiers in Neuroanatomy (Apr 2023)

Abnormal prenatal brain development in Chiari II malformation

  • Olivia Masse,
  • Emily Kraft,
  • Esha Ahmad,
  • Caitlin K. Rollins,
  • Clemente Velasco-Annis,
  • Edward Yang,
  • Simon Keith Warfield,
  • Alireza A. Shamshirsaz,
  • Ali Gholipour,
  • Henry A. Feldman,
  • Judy Estroff,
  • Judy Estroff,
  • Patricia Ellen Grant,
  • Patricia Ellen Grant,
  • Lana Vasung

DOI
https://doi.org/10.3389/fnana.2023.1116948
Journal volume & issue
Vol. 17

Abstract

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IntroductionThe Chiari II is a relatively common birth defect that is associated with open spinal abnormalities and is characterized by caudal migration of the posterior fossa contents through the foramen magnum. The pathophysiology of Chiari II is not entirely known, and the neurobiological substrate beyond posterior fossa findings remains unexplored. We aimed to identify brain regions altered in Chiari II fetuses between 17 and 26 GW.MethodsWe used in vivo structural T2-weighted MRIs of 31 fetuses (6 controls and 25 cases with Chiari II).ResultsThe results of our study indicated altered development of diencephalon and proliferative zones (ventricular and subventricular zones) in fetuses with a Chiari II malformation compared to controls. Specifically, fetuses with Chiari II showed significantly smaller volumes of the diencephalon and significantly larger volumes of lateral ventricles and proliferative zones.DiscussionWe conclude that regional brain development should be taken into consideration when evaluating prenatal brain development in fetuses with Chiari II.

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