Increased Serum Sialic Acids in Depression.

Abstract

Background: Total serum sialic acid (TSA) and lipid associated sialic acid (LSA) have not been measured yet in depressive disorders. Aim :The present study was undertaken to show if there is any change in the concentration of different forms of sialic acids in patients with depressive disorder. Methods: TSA and LSA levels have been estimated in serum of 72 patients with depression, in addition to 50 healthy controls . Results reflect a significant increase (p<0.05) in the TSA and BSA in the depressed patients as compared with healthy controls. Conclusions: It could be concluded that TSA and BSA could reflect an immune like response to depression associated with increase in the sialylation of different glycoproteins.

Keywords

• Serum Total Sialic acid , Depression , Free Sialic acid , Bound Sialic acid , Lipid Associated Sialic acid.