Allen Human Brain Atlas and magnetic resonance imaging in schizophrenia

Abstract

Schizophrenia is among top disability causes worldwide; however, its pathological mechanism is still unclear. In order to advance the research progress on schizophrenia, the Schizophrenia Imaging Lab has been dedicated to the diagnosis, treatment, and prevention of schizophrenia and conducted systematic studies. One of the recent studies involved the Allen Human Brain Atlas in the imaging study of schizophrenia. The combination of the two methods mitigated the gap between the human brain imaging and genetic mechanism, and enabled us to observe the transcriptome alterations and brain changes at the same time. This review concluded the studies that combined the imaging method and the Allen Human Brain Atlas application in schizophrenia. We aim to provide a holistic view of the brain changes in schizophrenia at the micro level.