A Rare Complication of Perianal Fistula: Mucinous Adenocarcinoma Developing Three Years After Diagnosis

Abstract

It is very rare to see perianal fistula(PF) and mucinous adenocarcinoma(MA) together. The underlying pathophysiology leading to malignant transformation is still not clear. For MA to develop, PF must be at least 10 years old, and this is one of the diagnostic criteria . However, Michihiro Koizumi et al. revealed the existence of a PF-related MA with a 3-year follow-up. In our case, the history of PF disease was 3 years. Although there is a risk of developing MA 10 years after diagnosis in patients with PF, it should be kept in mind that MA may also develop at an earlier period. Therefore, especially patients who are untreated and whose chronic inflammatory process continues in the fistula tract should be closely monitored for MA.

Keywords

• mucinous adenocarcinoma
• perianal fistulsa
• complication