Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function

Martin H. Berryer; Bidisha Chattopadhyaya; Paul Xing; Ilse Riebe; Ciprian Bosoi; Nathalie Sanon; Judith Antoine-Bertrand; Maxime Lévesque; Massimo Avoli; Fadi F. Hamdan; Lionel Carmant; Nathalie Lamarche-Vane; Jean-Claude Lacaille; Jacques L. Michaud; Graziella Di Cristo

doi:10.1038/ncomms13340

Nature Communications (Nov 2016)

Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function

Martin H. Berryer,
Bidisha Chattopadhyaya,
Paul Xing,
Ilse Riebe,
Ciprian Bosoi,
Nathalie Sanon,
Judith Antoine-Bertrand,
Maxime Lévesque,
Massimo Avoli,
Fadi F. Hamdan,
Lionel Carmant,
Nathalie Lamarche-Vane,
Jean-Claude Lacaille,
Jacques L. Michaud,
Graziella Di Cristo

Affiliations

Martin H. Berryer: Department of Neurosciences, Université de Montréal
Bidisha Chattopadhyaya: Department of Neurosciences, Université de Montréal
Paul Xing: Department of Neurosciences, Université de Montréal
Ilse Riebe: Department of Neurosciences, Université de Montréal
Ciprian Bosoi: CHU Sainte-Justine Research Center
Nathalie Sanon: CHU Sainte-Justine Research Center
Judith Antoine-Bertrand: Department of Anatomy and Cell Biology, Cancer Research Program of the Research Institute of MUHC, McGill University
Maxime Lévesque: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University
Massimo Avoli: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University
Fadi F. Hamdan: CHU Sainte-Justine Research Center
Lionel Carmant: Department of Neurosciences, Université de Montréal
Nathalie Lamarche-Vane: Department of Anatomy and Cell Biology, Cancer Research Program of the Research Institute of MUHC, McGill University
Jean-Claude Lacaille: Department of Neurosciences, Université de Montréal
Jacques L. Michaud: Department of Neurosciences, Université de Montréal
Graziella Di Cristo: Department of Neurosciences, Université de Montréal

DOI: https://doi.org/10.1038/ncomms13340
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Glutamatergic signalling regulation by Syngap1 has been linked to intellectual disabilities. Here, the authors find Syngap1 also regulates cortical GABAergic synaptic signalling development and that this reduced inhibitory signalling contributes to cognitive deficits in a mouse model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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