Clinical Medicine Insights: Case Reports (Jan 2008)

Nizatidine Improves Impaired Salivary Secretion in GERD

  • Yoshihisa Urita M.D., Ph.D., FACG,
  • Toshiyasu Watanabe,
  • Kazuo Hike,
  • Makie Nanami,
  • Tadashi Maeda,
  • Yosuke Sasaki,
  • Asuka Nakayama,
  • Takamasa Ishii,
  • Kaoru Domon,
  • Susumu Ishihara,
  • Masaki Sanaka,
  • Hitoshi Nakajima,
  • Motonobu Sugimoto

DOI
https://doi.org/10.4137/CCRep.S870
Journal volume & issue
Vol. 1

Abstract

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During esophageal acid clearance, salivation plays an important role in defending the esophageal mucosa. Nizatidine, a histamine H2 receptor antagonist, inhibits acetylcholine esterase, with a resultant increase in acetylcholine. We experienced a patient with gastroesophageal reflux disease (GERD) and impaired salivary secretion who has been successfully treated with nizatidine. Case report A 63-year-old female visited our hospital with complaints of heartburn and continuous laryngeal discomfort. Saliva scintigraphy was performed to evaluate the salivary function. Washout ratio was decreased to be 25%–40% in individual salivary gland. After the treatment with nizatidine, salivary scintigraphy demonstrated the increased washout ratios. The values of both parotid glands increased up to 90%, whereas those of submandibular glands improved to be around a normal range. GERD symptoms disappeared completely after treatment. In conclusion, nizatidine may be one of therapeutic options for low salivary excretion.