A new in vitro dormancy model of <i>Mycobacterium tuberculosis</i>

Abstract

The article describes a new in vitro dormancy model of M. tuberculosis based on cultivation with deprivation of four components of the standard medium of Mediumbrook 7H9. The modeling method and characteristics of the obtained dormant phenotype of M. tuberculosis are described in detail, and fields for potential application of the model are proposed.

Keywords

• mycobacterium tuberculosis
• дормантность микобактерий туберкулеза
• модели дормантности m. tuberculosis in vitro
• старвация
• депривация компонентов питательных сред