Nature Communications (Mar 2020)
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
- Christina A. von Roemeling,
- Yifan Wang,
- Yaqing Qie,
- Hengfeng Yuan,
- Hai Zhao,
- Xiujie Liu,
- Zhaogang Yang,
- Mingming Yang,
- Weiye Deng,
- Katelyn A. Bruno,
- Charles K. Chan,
- Andrew S. Lee,
- Stephen S. Rosenfeld,
- Kyuson Yun,
- Aaron J. Johnson,
- Duane A. Mitchell,
- Wen Jiang,
- Betty Y. S. Kim
Affiliations
- Christina A. von Roemeling
- Graduate School of Biomedical Science, Mayo Clinic
- Yifan Wang
- Department of Radiation Oncology, The University of Texas Southwestern Medical Center
- Yaqing Qie
- Department of Neurosurgery, Mayo Clinic
- Hengfeng Yuan
- Department of Neurosurgery, Mayo Clinic
- Hai Zhao
- Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
- Xiujie Liu
- Department of Neurosurgery, Mayo Clinic
- Zhaogang Yang
- Department of Radiation Oncology, The University of Texas Southwestern Medical Center
- Mingming Yang
- Department of Radiation Oncology, The University of Texas Southwestern Medical Center
- Weiye Deng
- Department of Radiation Oncology, The University of Texas Southwestern Medical Center
- Katelyn A. Bruno
- Department of Cardiology, Mayo Clinic
- Charles K. Chan
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Andrew S. Lee
- Department of Pathology, Stanford School of Medicine
- Stephen S. Rosenfeld
- Department of Cancer Biology, Mayo Clinic
- Kyuson Yun
- Department of Neurosurgery, Houston Methodist Research Institute
- Aaron J. Johnson
- Department of Immunology, Mayo Clinic
- Duane A. Mitchell
- University of Florida Brain Tumor Immunotherapy Program, Preston A. Wells Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery, University of Florida
- Wen Jiang
- Department of Radiation Oncology, The University of Texas Southwestern Medical Center
- Betty Y. S. Kim
- Department of Neurosurgery, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-020-15129-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Professional antigen presenting cells (APCs) are deterred from phagocytosing cancer cells that express CD47. Here, the authors show that in glioblastoma mouse models, temozolomide improves the phagocytosis effect of CD47 blockade in APCs and results in the activation of adaptive anti-tumour responses.
