Journal of the Serbian Chemical Society (Jan 2015)
Green one-pot, four-component synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives using amino-functionalized nanoporous silica SBA-15 under solvent-free conditions
Abstract
Propylamine functionalized nanoporous silica (SBA-Pr-NH2) has been used as an efficient heterogeneous solid basic nanoreactor in the synthesis of 6'-amino-1'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazol]-2-one derivatives 5 through one-pot, four component condensation of isatin derivatives 1, activated methylene reagents 2, hydrazine hydrate 3 and β-keto esters 4 under solvent free conditions at room temperature
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