Nature Communications (Apr 2020)
Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis
- Vugar Azizov,
- Katharina Dietel,
- Franziska Steffen,
- Kerstin Dürholz,
- Julia Meidenbauer,
- Sébastien Lucas,
- Michael Frech,
- Yasunori Omata,
- Narges Tajik,
- Lisa Knipfer,
- Anne Kolenbrander,
- Silvia Seubert,
- Dennis Lapuente,
- Maria V. Sokolova,
- Jörg Hofmann,
- Matthias Tenbusch,
- Andreas Ramming,
- Ulrike Steffen,
- Falk Nimmerjahn,
- Ralf Linker,
- Stefan Wirtz,
- Martin Herrmann,
- Vladimir Temchura,
- Kerstin Sarter,
- Georg Schett,
- Mario M. Zaiss
Affiliations
- Vugar Azizov
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Katharina Dietel
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Franziska Steffen
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Kerstin Dürholz
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Julia Meidenbauer
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Sébastien Lucas
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Michael Frech
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Yasunori Omata
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Narges Tajik
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Lisa Knipfer
- Department of Internal Medicine 1
- Anne Kolenbrander
- Department of Molecular and Medical Virology, Ruhr-University
- Silvia Seubert
- Department of Neurology
- Dennis Lapuente
- Institute of Clinical and Molecular Virology, University Hospital Erlangen
- Maria V. Sokolova
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Jörg Hofmann
- Division of Biochemistry, Department of Biology
- Matthias Tenbusch
- Institute of Clinical and Molecular Virology, University Hospital Erlangen
- Andreas Ramming
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Ulrike Steffen
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Falk Nimmerjahn
- Department of Biology, Institute of Genetics
- Ralf Linker
- Department of Neurology, University Hospital Regensburg
- Stefan Wirtz
- Department of Internal Medicine 1
- Martin Herrmann
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Vladimir Temchura
- Institute of Clinical and Molecular Virology, University Hospital Erlangen
- Kerstin Sarter
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Georg Schett
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Mario M. Zaiss
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- DOI
- https://doi.org/10.1038/s41467-020-15855-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Moderate consumption of alcohol is associated with protection from some autoimmune diseases. Here the authors show that ethanol and its metabolite acetate can protect mice from collagen-induced arthritis and provide evidence that the mechanism of this effect might be via inhibition of the effector function of T follicular helper cells.
