In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs

Hiroyuki Saito; Ryuichi Kambayashi; Ai Goto; Mihoko Hagiwara-Nagasawa; Kiyotaka Hoshiai; Yoshio Nunoi; Hiroko Izumi-Nakaseko; Yasuki Akie; Yoshinori Takei; Akio Matsumoto; Atsushi Sugiyama

Journal of Pharmacological Sciences (Mar 2021)

In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs

Hiroyuki Saito,
Ryuichi Kambayashi,
Ai Goto,
Mihoko Hagiwara-Nagasawa,
Kiyotaka Hoshiai,
Yoshio Nunoi,
Hiroko Izumi-Nakaseko,
Yasuki Akie,
Yoshinori Takei,
Akio Matsumoto,
Atsushi Sugiyama

Affiliations

Hiroyuki Saito: Bioresearch Center, CMIC Pharma Science Co., Ltd 10221, Kobuchisawa, Hokuto, Yamanashi 408-0044, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Ryuichi Kambayashi: Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Ai Goto: Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Mihoko Hagiwara-Nagasawa: Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Kiyotaka Hoshiai: Bioresearch Center, CMIC Pharma Science Co., Ltd 10221, Kobuchisawa, Hokuto, Yamanashi 408-0044, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Yoshio Nunoi: Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Hiroko Izumi-Nakaseko: Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Yasuki Akie: Bioresearch Center, CMIC Pharma Science Co., Ltd 10221, Kobuchisawa, Hokuto, Yamanashi 408-0044, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Yoshinori Takei: Department of Translational Research & Cellular Therapeutics, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Akio Matsumoto: Department of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Atsushi Sugiyama: Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan; Department of Translational Research & Cellular Therapeutics, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan; Department of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan; Corresponding author. Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan. Fax: +81 3 5493 5413.

Journal volume & issue: Vol. 145, no. 3
pp. 268 – 272

Abstract

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We assessed concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables using a cross-over design in intact beagle dogs (n = 4). Elevation of inhaled halothane from 1.0% to 2.0% or isoflurane from 1.5% to 2.5% decreased the mean blood pressure and prolonged the QRS width without significantly altering the heart rate, PR interval or QT interval. However, the observed changes disappeared after regressions of both anesthetic conditions to their initial settings. These results indicate that hypotension-induced, reflex-mediated increase of sympathetic tone may have counterbalanced the direct negative chronotropic, dromotropic and repolarization slowing effects of the anesthetics.

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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