Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

Abdel-Hamid Heba A.; Maqsoud Nehad MR. Abdel; Toni Nisreen DM.; Ahmed Rasha F.; Abdel-Hakeem Elshymaa A.

doi:10.2478/enr-2023-0004

Endocrine Regulations (Jan 2023)

Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

Abdel-Hamid Heba A.,
Maqsoud Nehad MR. Abdel,
Toni Nisreen DM.,
Ahmed Rasha F.,
Abdel-Hakeem Elshymaa A.

Affiliations

Abdel-Hamid Heba A.: Medical Physiology Department, Faculty of Medicine, Minia University, Minia, Egypt
Maqsoud Nehad MR. Abdel: Pathology Department, Faculty of Medicine, Delegated to Deraya University New Minia City, Minia University, Minia, Egypt
Toni Nisreen DM.: Pathology Department, Faculty of Medicine, Minia University, Minia, Egypt
Ahmed Rasha F.: Biochemistry Department, Faculty of Medicine, Minia University, Minia, Egypt
Abdel-Hakeem Elshymaa A.: Medical Physiology Department, Faculty of Medicine, Minia University, Minia, Egypt

DOI: https://doi.org/10.2478/enr-2023-0004
Journal volume & issue: Vol. 57, no. 1
pp. 25 – 36

Abstract

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Objective. Ovarian torsion is a gynecological emergency that occurs mostly during the female reproductive years due to ovarian masses or surgical manipulation. This work aims to explore the probable protective effect of leptin on rat ovaries due to ischemia-reperfusion (IR) injury.

Published in Endocrine Regulations

ISSN: 1336-0329 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://sciendo.com/journal/ENR

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