Антибиотики и Химиотерапия (Nov 2020)

Antibiotic-Resistant Uropathogenic <i>Escherichia coli</i> Isolated from Children with Congenital Abnormalities of the Kidneys and Urinary Tract

  • S. Suadkia,
  • I. V. Podoprigora,
  • N. V. Yashina,
  • L. E. Sarukhanova,
  • E. G. Kravtsov

DOI
https://doi.org/10.37489/0235-2990-2020-65-7-8-23-26
Journal volume & issue
Vol. 65, no. 7-8
pp. 23 – 26

Abstract

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Uropathogenic Escherichia coli (UPEC) is a serious health problem worldwide. UPEC's multiple drug resistance combined with virulence factors is a cause of serious concern. In childhood, urinary tract infections are of particular importance, since they can occur against the background of long-term unrecognized congenital anomalies of the kidneys and urinary tract. Of the 106 UPEC clinical isolates, 63.2% of cultures were isolated from girls' urine samples and 36.8% from boys' urine samples, which corresponds to a 1.7: 1 ratio. The antibiotic resistance of the isolated UPEC cultures was assessed in relation to 12 antimicrobial drugs. Among the tested cultures, 49% were multidrug-resistant and 20.75% were found to be resistant to imipenem. Phenotypic analysis of antibiotic susceptibility spectrum of uropathogenic E.coli (n=106) indicates a high percentage of occurrence of multi-resistant UPEC strains (49%) and imipenem-resistant UPEC strains (20.75%) among children of all age groups.

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