Nature Communications (Sep 2020)

Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex

  • B. O. Forsberg,
  • S. Aibara,
  • R. J. Howard,
  • N. Mortezaei,
  • E. Lindahl

DOI
https://doi.org/10.1038/s41467-020-18401-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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The pyruvate dehydrogenase complex (PDC) is a multienzyme complex connecting glycolysis to mitochondrial oxidation of pyruvate. Cryo-EM analysis of PDC from Neurospora crassa reveals localization of fungi-specific protein X (PX) and confirms that it functions like the mammalian E3BP, recruiting the E3 component of PDC.