Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage

Arne Praznik; Tina Fink; Nik Franko; Jan Lonzarić; Mojca Benčina; Nina Jerala; Tjaša Plaper; Samo Roškar; Roman Jerala

doi:10.1038/s41467-022-28971-9

Nature Communications (Mar 2022)

Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage

Arne Praznik,
Tina Fink,
Nik Franko,
Jan Lonzarić,
Mojca Benčina,
Nina Jerala,
Tjaša Plaper,
Samo Roškar,
Roman Jerala

Affiliations

Arne Praznik: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Tina Fink: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Nik Franko: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Jan Lonzarić: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Mojca Benčina: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Nina Jerala: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Tjaša Plaper: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Samo Roškar: Department of Synthetic Biology and Immunology, National Institute of Chemistry
Roman Jerala: Department of Synthetic Biology and Immunology, National Institute of Chemistry

DOI: https://doi.org/10.1038/s41467-022-28971-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Secreted proteins, such as hormones or cytokines, are key mediators in multicellular organisms. Here the authors present two genetically encoded orthogonal regulatory secretion systems that enables inducible protein release and construction of logic gates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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