High strength HA-PEG/NAGA-Gelma double network hydrogel for annulus fibrosus rupture repair

Yichen Zhang; Huichang Gao; Huitong Luo; Dafu Chen; Zhiyu Zhou; Xiaodong Cao

Smart Materials in Medicine (Jan 2022)

High strength HA-PEG/NAGA-Gelma double network hydrogel for annulus fibrosus rupture repair

Yichen Zhang,
Huichang Gao,
Huitong Luo,
Dafu Chen,
Zhiyu Zhou,
Xiaodong Cao

Affiliations

Yichen Zhang: School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China; National Engineering Research Centre for Tissue Restoration and Reconstruction, Guangzhou, 510006, PR China
Huichang Gao: School of Medicine, South China University of Technology, Guangzhou, 510006, PR China; National Engineering Research Centre for Tissue Restoration and Reconstruction, Guangzhou, 510006, PR China
Huitong Luo: School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China; National Engineering Research Centre for Tissue Restoration and Reconstruction, Guangzhou, 510006, PR China
Dafu Chen: Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Orthopaedics and Traumatology, Beijing JiShuiTan Hospital, Beijing, 100035, PR China
Zhiyu Zhou: Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury, Department of Orthopedic Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, PR China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Xiaodong Cao: School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China; National Engineering Research Centre for Tissue Restoration and Reconstruction, Guangzhou, 510006, PR China; Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, PR China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006, PR China; Corresponding author. School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.

Journal volume & issue: Vol. 3
pp. 128 – 138

Abstract

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The low back pain (LBP) caused by intervertebral disc (IVD) herniation and degeneration bring huge physical and economic burden to individuals and families. Since current clinical treatment methods could not change the degeneration process of the intervertebral disc, annulus fibrosus (AF) repair as a method to seal defects of the IVD and prevent reherniation after lumbar discectomy has attracted increasing interest. In this study, a porous HA-PEG/NAGA-GelMA double network hydrogel with the multiple hydrogen bonds was designed and prepared by a two-step method, in which the multiple hydrogen bonds produced by NAGA endowed excellent mechanical properties (compressive strength up to 1.19 MPa and compressive modulus up to 0.55 MPa) to resist the pressure from the AF and the hyaluronic acid provided good biological activity. In vitro cell experiment indicated that the double network hydrogel possessed good cytocompatibility and supported cell proliferation and penetration. In addition, further organ experiments also showed that the double network hydrogel could restore the disc height and mechanical function of the injured intervertebral disc, and display good integration with the host AF, showing a promising application in annulus fibrosus tissue repair after lumbar discectomy.

Published in Smart Materials in Medicine

ISSN: 2590-1834 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology
Website: https://www.keaipublishing.com/en/journals/smart-materials-in-medicine/

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