Nature Communications (Jul 2020)

Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state

  • Takeshi Kawabe,
  • Jaeu Yi,
  • Akihisa Kawajiri,
  • Kerry Hilligan,
  • Difeng Fang,
  • Naoto Ishii,
  • Hidehiro Yamane,
  • Jinfang Zhu,
  • Dragana Jankovic,
  • Kwang Soon Kim,
  • Giorgio Trinchieri,
  • Alan Sher

DOI
https://doi.org/10.1038/s41467-020-17136-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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CD4+ T cells contain a T-bethigh memory-phenotype (MP) population with innate-like functions. Here the authors characterize the requirements for their differentiation at homeostasis and identify a function for IL-12 that is tonically produced by type 1 dendritic cells in an MyD88- and CD40-dependent, but foreign PAMP-independent manner.