Molecules (Oct 2022)

Polymorph Separation by Ordered Patterning

  • Massimiliano Cavallini,
  • Marco Brucale,
  • Denis Gentili,
  • Fabiola Liscio,
  • Lucia Maini,
  • Laura Favaretto,
  • Ilse Manet,
  • Massimo Zambianchi,
  • Manuela Melucci

DOI
https://doi.org/10.3390/molecules27217235
Journal volume & issue
Vol. 27, no. 21
p. 7235

Abstract

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We herein address the problem of polymorph selection by introducing a general and straightforward concept based on their ordering. We demonstrated the concept by the ordered patterning of four compounds capable of forming different polymorphs when deposited on technologically relevant surfaces. Our approach exploits the fact that, when the growth of a crystalline material is confined within sufficiently small cavities, only one of the possible polymorphs is generated. We verify our method by utilizing several model compounds to fabricate micrometric “logic patterns” in which each of the printed pixels is easily identifiable as comprising only one polymorph and can be individually accessed for further operations.

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