BMJ Open (Jun 2024)
TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease
- ,
- Tommi Vasankari,
- Henri Vähä-Ypyä,
- Oskari Heikinheimo,
- Athena Matakidou,
- Jaakko Kaprio,
- Eero Vuoksimaa,
- Ying Wu,
- Kai Kaarniranta,
- Peeter Karihtala,
- Wei Zhou,
- Caroline Fox,
- Sanna-Kaisa Herukka,
- Sarah Smith,
- Apinya Lertratanakul,
- Katri Kaukinen,
- Johannes Kettunen,
- Minna Männikkö,
- Eeva Sliz,
- Markus Perola,
- Veikko Salomaa,
- Hilkka Soininen,
- Ilkka Kalliala,
- Mika Kähönen,
- Hao Chen,
- Andrey Loboda,
- Laure Morin-Papunen,
- Terhi Piltonen,
- Anders Mälarstig,
- Jason Miller,
- Jussi Hernesniemi,
- Henrike Heyne,
- Sirkku Peltonen,
- Daniel Gordin,
- Masahiro Kanai,
- Benjamin Challis,
- Juha Sinisalo,
- David Rice,
- Fredrik Åberg,
- Aarno Palotie,
- Samuli Ripatti,
- Oili Kaipiainen-Seppänen,
- Aki Havulinna,
- Satu Strausz,
- Tuomo Kiiskinen,
- Sanni Ruotsalainen,
- Jukka Koskela,
- Tuula Palotie,
- Mark Daly,
- Howard Jacob,
- Heiko Runz,
- Sally John,
- Robert Plenge,
- Mark McCarthy,
- Julie Hunkapiller,
- Dawn Waterworth,
- Petri Virolainen,
- Terhi Kilpi,
- Jukka Partanen,
- Anne Pitkäranta,
- Veli-Matti Kosma,
- Outi Tuovila,
- Raimo Pakkanen,
- Shameek Biswas,
- Xinli Hu,
- Johanna Schleutker,
- Mikko Arvas,
- Olli Carpen,
- Reetta Hinttala,
- Arto Mannermaa,
- Valtteri Julkunen,
- Anne Remes,
- Reetta Kälviäinen,
- Mikko Hiltunen,
- Jukka Peltola,
- Pentti Tienari,
- Juha Rinne,
- Adam Ziemann,
- Jeffrey Waring,
- Nizar Smaoui,
- Anne Lehtonen,
- Susan Eaton,
- Sanni Lahdenperä,
- Natalie Bowers,
- Edmond Teng,
- Fanli Xu,
- David Pulford,
- Martti Färkkilä,
- Sampsa Pikkarainen,
- Airi Jussila,
- Timo Blomster,
- Mikko Kiviniemi,
- Markku Voutilainen,
- Fedik Rahimov,
- Joseph Maranville,
- Tim Lu,
- Kirsi Kalpala,
- Melissa Miller,
- Linda McCarthy,
- Kari Eklund,
- Antti Palomäki,
- Pia Isomäki,
- Laura Pirilä,
- Johanna Huhtakangas,
- Marla Hochfeld,
- Nan Bing,
- Jorge Esparza Gordillo,
- Nina Mars,
- Tarja Laitinen,
- Margit Pelkonen,
- Paula Kauppi,
- Hannu Kankaanranta,
- Terttu Harju,
- Hubert Chen,
- Teemu Niiranen,
- Kaj Metsärinne,
- Marja-Riitta Taskinen,
- Tiinamaija Tuomi,
- Jari Laukkanen,
- Audrey Chu,
- Jaakko Parkkinen,
- Heikki Joensuu,
- Tuomo Meretoja,
- Lauri Aaltonen,
- Annika Auranen,
- Päivi Auvinen,
- Klaus Elenius,
- Relja Popovic,
- Bridget Riley-Gillis,
- Jennifer Schutzman,
- Heli Lehtonen,
- Stefan McDonough,
- Diptee Kulkarni,
- Terhi Ollila,
- Hannu Uusitalo,
- Erich Strauss,
- Kaisa Tasanen,
- Laura Huilaja,
- Katariina Hannula-Jouppi,
- Teea Salmi,
- Leena Koulu,
- David Choy,
- Anu Jalanko,
- Risto Kajanne,
- Mari Kaunisto,
- Chia-Yen Chen,
- Robert Yang,
- Kirsi Auro,
- Clement Chatelain,
- Mitja Kurki,
- Juha Karjalainen,
- Kimmo Palin,
- Priit Palta,
- Susanna Lemmelä,
- Manuel Rivas,
- Arto Lehisto,
- Andrea Ganna,
- Vincent Llorens,
- Kati Kristiansson,
- Kati Hyvärinen,
- Jarmo Ritari,
- Katri Pylkäs,
- Minna Karjalainen,
- Tuomo Mantere,
- Eeva Kangasniemi,
- Sami Heikkinen,
- Eija Laakkonen,
- Anu Loukola,
- Päivi Laiho,
- Tuuli Sistonen,
- Essi Kaiharju,
- Markku Laukkanen,
- Elina Järvensivu,
- Sini Lähteenmäki,
- Lotta Männikkö,
- Regis Wong,
- Hannele Mattsson,
- Tero Hiekkalinna,
- Kati Donner,
- Kalle Pärn,
- Elina Kilpeläinen,
- Hannele Laivuori,
- Harri Siirtola,
- Sirpa Soini,
- Teijo Kuopio,
- Ioanna Tachmazidou,
- Katja Kivinen,
- Pekka Nieminen,
- Adam Platt,
- Sanna Toppila-Salmi,
- Antti Mäkitie,
- Elmo Saarentaus,
- Kristiina Aittomäki,
- Elisabeth Widen,
- Marja Vääräsmäki,
- Erkki Isometsä,
- Laura Addis,
- Mika Helminen,
- Taneli Raivio,
- Mart Kals,
- Majd Mouded,
- Hanna Ollila,
- Vuokko Anttonen,
- Tarja Kokkola,
- Robert Graham,
- Amanda Elliott,
- Ali Abbasi,
- Bridget Riley-Gills,
- Dirk Paul,
- Katherine Klinger,
- Deepak Raipal,
- Antti Hakanen,
- Raisa Serpi,
- Johanna Mäkelä,
- Mengzhen Liu,
- Neha Raghavan,
- Adriana Huertas-Vazquez,
- Nicole Renaud,
- Roosa Kallionpää,
- John Eicher,
- Minna Raivio,
- Juulia Partanen,
- Riitta Lahesmaa,
- Glenda Lassi,
- Joanna Betts,
- Rajashree Mishra,
- Felix Vaura,
- Joel Rämö,
- Mary Pat Reeve,
- Johanna Mattson,
- Sauli Vuoti,
- Esa Pitkänen,
- Joni A Turunen,
- Stephanie Loomis,
- Pirkko Pussinen,
- Aino Salminen,
- Tuula Salo,
- Ulla Palotie,
- Maria Siponen,
- Liisa Suominen,
- Päivi Mäntylä,
- Ulvi Gursoy,
- Kirsi Sipilä,
- Venla Kurra,
- Laura Kotaniemi-Talonen,
- Outi Uimari,
- Taru Tukiainen,
- Niko Välimäki,
- Janet Kumar,
- Juha Mehtonen,
- Shabbeer Hassan,
- Pietro Della Briotta Parolo,
- Mutaamba Maasha,
- Javier Garcia-Tabuenca,
- Jiwoo Lee,
- Kristin Tsuo,
- Nina Pitkänen,
- Eero Punkka,
- Huei-Yi Shen,
- Mervi Aavikko,
- L. Elisa Lahtela,
- Timo P. Sipilä,
- Awaisa Ghazal,
- Sami Koskelainen,
- Shuang Luo,
- Javier Gracia-Tabuenca,
- Tiina Luukkaala,
- Iida Vähätalo,
- Marco Hautalahti,
- Tom Southerington,
- Paula Iso-Markku,
- Jaana Suvisaari,
- Zhihao Ding,
- Qingqin S Li,
- Amy Hart,
- Perttu Terho,
- Alessandro Porello,
- Anastasia Kytölä,
- Antti Aarnisalo,
- Aoxing Liu,
- Argyro Bizaki-Vallaskangas,
- Auli Toivola,
- Debby Ngo,
- Dermot Reilly,
- Ekaterina Khramtsova,
- Elisa Rahikkala,
- Eric Green,
- Eveliina Salminen,
- Fabiana Farias,
- George Okafo,
- Heidi Silven,
- Heli Salminen-Mankonen,
- Henna Palin,
- Iiris Hovatta,
- Jaakko Tyrmi,
- Jae-Hoon Sul,
- Jenni Aittokallio,
- Jyrki Pitkänen,
- Karen He,
- Katriina Aalto-Setälä,
- Maarit Niinimäki,
- Malla-Maria Linna,
- Marc Jung,
- Margaret G. Ehm,
- Marianna Niemi,
- Meijian Guan,
- Mike Mendelson,
- Minna Brunfeldt,
- Natalia Pujol,
- Nathan Lawless,
- Oluwaseun Alexander Dada,
- Rigbe Weldatsadik,
- Riikka Arffman,
- Rion Pendergrass,
- Sahar Mozaffari,
- Samuel Lessard,
- Sanna Siltanen,
- Shanmukha Sampath Padmanabhuni,
- Simonne Longerich,
- Susanna Savukoski,
- Thomas Damm Als,
- Timo Hiltunen,
- Tomi P. Mäkelä,
- Triin Laisk,
- Tytti Willberg,
- Varpu Jokimaa,
- Aija Kyttälä,
- Toni T Saari,
- Aino Aaltonen,
- Sari Aaltonen,
- Sari Kärkkäinen,
- Hilkka Liedes,
- Miina Ollikainen,
- Teemu Palviainen,
- Ilona Ruotsalainen,
- Mia Urjansson,
- Markus M Forsberg,
- Jaakko Lähteenmäki,
- Pia Nyberg,
- Jani Tikkanen,
- Mari E. Niemi,
- Rodos Rodosthenous
Affiliations
- Tommi Vasankari
- 2UKK Institute, Tampere, Finland
- Henri Vähä-Ypyä
- UKK Institute for Health Promotion Research, Tampere, Finland
- Oskari Heikinheimo
- chief physician
- Athena Matakidou
- Jaakko Kaprio
- 2 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Eero Vuoksimaa
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
- Ying Wu
- Department of Medical Oncology, Changzheng Hospital, Naval Medical University, Shanghai, People`s Republic of China
- Kai Kaarniranta
- Peeter Karihtala
- Wei Zhou
- Eye and Dental Diseases Prevention & Treatment Center of Pudong New Area, Shanghai, China
- Caroline Fox
- Sanna-Kaisa Herukka
- Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland
- Sarah Smith
- 3 Royal Free Hospital, London, UK
- Apinya Lertratanakul
- Katri Kaukinen
- 8 Faculty of Medicine and Health Technology, Tampere University and Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
- Johannes Kettunen
- Minna Männikkö
- 16 Northern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, Oulu, Finland
- Eeva Sliz
- Markus Perola
- Finnish Institute for Health and Welfare, Helsinki, Finland
- Veikko Salomaa
- 21 Finnish Institute for Health and Welfare, Helsinki, Uusimaa, Finland
- Hilkka Soininen
- Ilkka Kalliala
- Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
- Mika Kähönen
- 6 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
- Hao Chen
- 1 Department of Pathology, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, Jiangsu, China
- Andrey Loboda
- Merck & Co., Inc, Rahway, New Jersey, USA
- Laure Morin-Papunen
- Terhi Piltonen
- Anders Mälarstig
- Jason Miller
- General Surgery, Royal Brisbane and Women`s Hospital, Herston, Queensland, Australia
- Jussi Hernesniemi
- Henrike Heyne
- Sirkku Peltonen
- Daniel Gordin
- Masahiro Kanai
- 3Osaka University Graduate School of Medicine, Department of Statistical Genetics, Suita, Japan
- Benjamin Challis
- Juha Sinisalo
- University of Helsinki, Helsinki, Finland
- David Rice
- Health and Rehabilitation Research Institute, School of Clinical Sciences, Auckland University of Technology, Auckland, New Zealand
- Fredrik Åberg
- 1 Transplantation and Liver Surgery, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland
- Aarno Palotie
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
- Samuli Ripatti
- Oili Kaipiainen-Seppänen
- 6Kuopio University hospital, Department of Medicine, Kuopio, Finland
- Aki Havulinna
- Satu Strausz
- Tuomo Kiiskinen
- Sanni Ruotsalainen
- Jukka Koskela
- Tuula Palotie
- Mark Daly
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
- Howard Jacob
- Heiko Runz
- Translational Biology, Research and Development, Biogen Inc, Cambridge, Massachusetts, USA
- Sally John
- Robert Plenge
- Mark McCarthy
- 1 Department of Clinical Education, University Hospitals of Leicester NHS Trust, Leicester, UK
- Julie Hunkapiller
- Dawn Waterworth
- Janssen Research and Development, LLC, Spring House, PA
- Petri Virolainen
- Terhi Kilpi
- Jukka Partanen
- Anne Pitkäranta
- Veli-Matti Kosma
- Outi Tuovila
- Raimo Pakkanen
- Shameek Biswas
- Xinli Hu
- Johanna Schleutker
- Mikko Arvas
- Olli Carpen
- Reetta Hinttala
- Arto Mannermaa
- Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland
- Valtteri Julkunen
- 2 Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
- Anne Remes
- Reetta Kälviäinen
- 2 Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
- Mikko Hiltunen
- Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
- Jukka Peltola
- Pentti Tienari
- Juha Rinne
- Adam Ziemann
- Jeffrey Waring
- Nizar Smaoui
- Anne Lehtonen
- Susan Eaton
- Sanni Lahdenperä
- Natalie Bowers
- Edmond Teng
- Fanli Xu
- David Pulford
- Martti Färkkilä
- professor
- Sampsa Pikkarainen
- Airi Jussila
- Timo Blomster
- Mikko Kiviniemi
- Markku Voutilainen
- Fedik Rahimov
- Joseph Maranville
- Tim Lu
- Kirsi Kalpala
- Melissa Miller
- Division of Healthcare-Associated Infections, Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, Maryland, USA
- Linda McCarthy
- Kari Eklund
- EuroSpA Research Collaboration, On behalf of the DANBIO (Denmark), ARTIS (Sweden), SCQM (Switzerland), NOR-DMARD (Norway), ATTRA (Czech Republic), Reuma.pt (Portugal), BIOBADASER (Spain), ROB-FIN (Finland), biorx.si (Slovenia), ICEBIO (Iceland), TURKBIO (Turkey), RRBR (Romania), ARC (Netherlands), BSRBR-AS (UK), GISEA (Italy), Denmark
- Antti Palomäki
- Pia Isomäki
- Centre for Rheumatology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere, Finland
- Laura Pirilä
- 7Karolinska Institute, Division of Rheumatology, Department of Medicine, Stockholm, Sweden
- Johanna Huhtakangas
- Marla Hochfeld
- Nan Bing
- 1D2M Biotherapeutics, Natick, MA, USA
- Jorge Esparza Gordillo
- Nina Mars
- Tarja Laitinen
- Margit Pelkonen
- Paula Kauppi
- Hannu Kankaanranta
- Terttu Harju
- Hubert Chen
- Teemu Niiranen
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Kaj Metsärinne
- Marja-Riitta Taskinen
- Tiinamaija Tuomi
- Jari Laukkanen
- Audrey Chu
- Jaakko Parkkinen
- Heikki Joensuu
- Tuomo Meretoja
- Lauri Aaltonen
- Annika Auranen
- 5Tays Cancer Centre, Tampere University Hospital and Tampere University, Tampere, Finland
- Päivi Auvinen
- Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland
- Klaus Elenius
- Relja Popovic
- Bridget Riley-Gillis
- Jennifer Schutzman
- Heli Lehtonen
- Stefan McDonough
- Diptee Kulkarni
- Terhi Ollila
- Hannu Uusitalo
- Erich Strauss
- Kaisa Tasanen
- Laura Huilaja
- Katariina Hannula-Jouppi
- Teea Salmi
- Leena Koulu
- David Choy
- Anu Jalanko
- 1 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Risto Kajanne
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
- Mari Kaunisto
- Chia-Yen Chen
- Robert Yang
- Kirsi Auro
- Clement Chatelain
- Mitja Kurki
- Juha Karjalainen
- Kimmo Palin
- Priit Palta
- Susanna Lemmelä
- Manuel Rivas
- Arto Lehisto
- Andrea Ganna
- Institute for Molecular Medicine, FIMM, University of Helsinki, Helsinki, Finland
- Vincent Llorens
- Kati Kristiansson
- Kati Hyvärinen
- Jarmo Ritari
- Katri Pylkäs
- Minna Karjalainen
- Tuomo Mantere
- Eeva Kangasniemi
- Sami Heikkinen
- Eija Laakkonen
- Anu Loukola
- Päivi Laiho
- Tuuli Sistonen
- Essi Kaiharju
- Markku Laukkanen
- Elina Järvensivu
- Sini Lähteenmäki
- Lotta Männikkö
- Regis Wong
- Hannele Mattsson
- Tero Hiekkalinna
- Kati Donner
- Kalle Pärn
- Elina Kilpeläinen
- Hannele Laivuori
- Medical and Clinical Genetics, Helsinki University Hospital, Helsinki, Finland
- Harri Siirtola
- Sirpa Soini
- Teijo Kuopio
- 12 Central Finland Biobank, Wellbeing Services County of Central Finland and University of Jyväskylä, Jyväskylä, Finland
- Ioanna Tachmazidou
- Katja Kivinen
- Pekka Nieminen
- Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
- Adam Platt
- Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
- Sanna Toppila-Salmi
- Antti Mäkitie
- Elmo Saarentaus
- Kristiina Aittomäki
- Elisabeth Widen
- Marja Vääräsmäki
- Erkki Isometsä
- Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
- Laura Addis
- Mika Helminen
- Health Sciences, Research Services, Tampere, Finland
- Taneli Raivio
- Mart Kals
- Majd Mouded
- Hanna Ollila
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Vuokko Anttonen
- Tarja Kokkola
- Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland
- Robert Graham
- 1Sport Injury Research Prevention Centre, Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada
- Amanda Elliott
- Ali Abbasi
- Centre for Observational Research, Amgen Ltd Uxbridge, Uxbridge, Middlesex, UK
- Bridget Riley-Gills
- Dirk Paul
- Katherine Klinger
- Deepak Raipal
- Antti Hakanen
- Raisa Serpi
- 13 Biobank Borealis of Northern Finland, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Oulu, Finland
- Johanna Mäkelä
- Finnish Biobank Cooperative, Helsinki, Finland
- Mengzhen Liu
- Neha Raghavan
- Adriana Huertas-Vazquez
- Nicole Renaud
- Roosa Kallionpää
- John Eicher
- Minna Raivio
- Juulia Partanen
- Riitta Lahesmaa
- Glenda Lassi
- Joanna Betts
- Rajashree Mishra
- Felix Vaura
- Joel Rämö
- Mary Pat Reeve
- Johanna Mattson
- Department of oncology, Helsinki University Central Hospital, Helsinki, Finland
- Sauli Vuoti
- Esa Pitkänen
- Joni A Turunen
- Stephanie Loomis
- Pirkko Pussinen
- Aino Salminen
- Tuula Salo
- Ulla Palotie
- Maria Siponen
- Liisa Suominen
- Päivi Mäntylä
- Ulvi Gursoy
- Kirsi Sipilä
- Venla Kurra
- Laura Kotaniemi-Talonen
- Department of Obstetrics and Gynaecology, Tampere University Hospital, Tampere, Finland
- Outi Uimari
- Taru Tukiainen
- Niko Välimäki
- Janet Kumar
- Juha Mehtonen
- Shabbeer Hassan
- Pietro Della Briotta Parolo
- Mutaamba Maasha
- Javier Garcia-Tabuenca
- Jiwoo Lee
- Department of Obstetrics and Gynaecology, St. Vincent’s hospital, College of Medicine, The Catholic university of Korea, Seoul, Korea, Republic of
- Kristin Tsuo
- Nina Pitkänen
- Eero Punkka
- Hospital District of Helsinki and Uusimaa, Helsinki, Finland
- Huei-Yi Shen
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
- Mervi Aavikko
- L. Elisa Lahtela
- Timo P. Sipilä
- Awaisa Ghazal
- Sami Koskelainen
- Shuang Luo
- Baotou Tumor Hospital, Clinical Oncology of Baotou Medical College, China
- Javier Gracia-Tabuenca
- Tiina Luukkaala
- Iida Vähätalo
- Marco Hautalahti
- Finnish Biobank Cooperative, Helsinki, Finland
- Tom Southerington
- Paula Iso-Markku
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
- Jaana Suvisaari
- Finnish Institute for Health and Welfare, Helsinki, Finland
- Zhihao Ding
- Department of Gastroenterology and Hepatology, Jinling College of Nanjing Medical University, Nanjing, Jiangsu, China
- Qingqin S Li
- Amy Hart
- 4 Janssen R&D, Spring House, Pennsylvania, USA
- Perttu Terho
- Turku University Hospital (TYKS), Turku, Finland
- Alessandro Porello
- Anastasia Kytölä
- Antti Aarnisalo
- Aoxing Liu
- Argyro Bizaki-Vallaskangas
- Auli Toivola
- 4 THL Biobank, Finnish Institute for Health and Welfare, Helsinki, Finland
- Debby Ngo
- Dermot Reilly
- Ekaterina Khramtsova
- Elisa Rahikkala
- Eric Green
- Eveliina Salminen
- Fabiana Farias
- George Okafo
- Heidi Silven
- Heli Salminen-Mankonen
- Henna Palin
- Iiris Hovatta
- Jaakko Tyrmi
- Jae-Hoon Sul
- Jenni Aittokallio
- Jyrki Pitkänen
- Karen He
- Katriina Aalto-Setälä
- Maarit Niinimäki
- consultant gynaecologist
- Malla-Maria Linna
- Marc Jung
- Margaret G. Ehm
- Marianna Niemi
- Meijian Guan
- 1Genmab, Princeton, NJ, USA
- Mike Mendelson
- Minna Brunfeldt
- Natalia Pujol
- Nathan Lawless
- Oluwaseun Alexander Dada
- Rigbe Weldatsadik
- Riikka Arffman
- Rion Pendergrass
- Sahar Mozaffari
- Samuel Lessard
- Sanna Siltanen
- 16 Finnish Clinical Biobank Tampere, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland
- Shanmukha Sampath Padmanabhuni
- Simonne Longerich
- Susanna Savukoski
- Thomas Damm Als
- Timo Hiltunen
- Tomi P. Mäkelä
- Triin Laisk
- Tytti Willberg
- Varpu Jokimaa
- Aija Kyttälä
- Finnish Institute for Health and Welfare, Helsinki, Finland
- Toni T Saari
- 1 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Aino Aaltonen
- 1 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Sari Aaltonen
- 1 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Sari Kärkkäinen
- 2 Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
- Hilkka Liedes
- 1 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Miina Ollikainen
- 1 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Teemu Palviainen
- 1 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Ilona Ruotsalainen
- 1 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Mia Urjansson
- 1 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
- Markus M Forsberg
- 10 School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
- Jaakko Lähteenmäki
- 7 VTT Technical Research Centre of Finland Ltd, Espoo, Finland
- Pia Nyberg
- 13 Biobank Borealis of Northern Finland, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Oulu, Finland
- Jani Tikkanen
- Mari E. Niemi
- Rodos Rodosthenous
- DOI
- https://doi.org/10.1136/bmjopen-2023-081947
- Journal volume & issue
-
Vol. 14,
no. 6
Abstract
Introduction A better understanding of the earliest stages of Alzheimer’s disease (AD) could expedite the development or administration of treatments. Large population biobanks hold the promise to identify individuals at an elevated risk of AD and related dementias based on health registry information. Here, we establish the protocol for an observational clinical recall and biomarker study called TWINGEN with the aim to identify individuals at high risk of AD by assessing cognition, health and AD-related biomarkers. Suitable candidates were identified and invited to participate in the new study among THL Biobank donors according to TWINGEN study criteria.Methods and analysis A multi-centre study (n=800) to obtain blood-based biomarkers, telephone-administered and web-based memory and cognitive parameters, questionnaire information on lifestyle, health and psychological factors, and accelerometer data for measures of physical activity, sedentary behaviour and sleep. A subcohort is being asked to participate in an in-person neuropsychological assessment (n=200) and wear an Oura ring (n=50). All participants in the TWINGEN study have genome-wide genotyping data and up to 48 years of follow-up data from the population-based older Finnish Twin Cohort (FTC) study of the University of Helsinki. The data collected in TWINGEN will be returned to THL Biobank from where it can later be requested for other biobank studies such as FinnGen that supported TWINGEN.Ethics and dissemination This recall study consists of FTC/THL Biobank/FinnGen participants whose data were acquired in accordance with the Finnish Biobank Act. The recruitment protocols followed the biobank protocols approved by Finnish Medicines Agency. The TWINGEN study plan was approved by the Ethics Committee of Hospital District of Helsinki and Uusimaa (number 16831/2022). THL Biobank approved the research plan with the permission no: THLBB2022_83.