The role of inflammation mechanisms in the development of predisposition to thrombosis and thromboembolism in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea

Abstract

The objective: to study the effect of sleep-related breathing disorders on the activation of blood coagulation reactions associated with systemic inflammation in patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea.Subjects and methods. An open prospective comparative study analyzed thrombogenic risk factors, markers of inflammation and insulin resistance in 65 patients with chronic obstructive pulmonary disease and concurrent obstructive sleep apnea, 26 of them received non-invasive ventilation as a part of their therapy (main group).Results. The blood levels of homocysteine and prothrombin fragments 1+2 are closely associated with the duration of nocturnal hypoxemia, concentrations of C-reactive protein, C-peptide, and endothelial vascular growth factor and can be managed with CPAP therapy.The authors state that they have no conflict of interests.

Keywords

• хроническая обструктивная болезнь легких
• синдром обструктивного апноэ сна
• гомоцистеин
• эндотелиальный сосудистый фактор роста