Nature Communications (Sep 2018)
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
- Anthea Di Rita,
- Angelo Peschiaroli,
- Pasquale D′Acunzo,
- Daniela Strobbe,
- Zehan Hu,
- Jens Gruber,
- Mads Nygaard,
- Matteo Lambrughi,
- Gerry Melino,
- Elena Papaleo,
- Jörn Dengjel,
- Said El Alaoui,
- Michelangelo Campanella,
- Volker Dötsch,
- Vladimir V. Rogov,
- Flavie Strappazzon,
- Francesco Cecconi
Affiliations
- Anthea Di Rita
- Department of Biology, University of Rome Tor Vergata
- Angelo Peschiaroli
- National Research Council of Italy (CNR), Institute of Translational Pharmacology IFT
- Pasquale D′Acunzo
- Department of Paediatric Haematology, Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital
- Daniela Strobbe
- Department of Biology, University of Rome Tor Vergata
- Zehan Hu
- Department of Biology, University of Fribourg
- Jens Gruber
- Institute of Biophysical and Center for Biomolecular Magnetic Resonance, Goethe University
- Mads Nygaard
- Computational Biology Laboratory, Danish Cancer Society Research Center
- Matteo Lambrughi
- Computational Biology Laboratory, Danish Cancer Society Research Center
- Gerry Melino
- Department of Experimental Medicine and Surgery, University of Rome Tor Vergata
- Elena Papaleo
- Computational Biology Laboratory, Danish Cancer Society Research Center
- Jörn Dengjel
- Department of Biology, University of Fribourg
- Said El Alaoui
- Covalab
- Michelangelo Campanella
- IRCCS- Regina Elena, National Cancer Institute
- Volker Dötsch
- Institute of Biophysical and Center for Biomolecular Magnetic Resonance, Goethe University
- Vladimir V. Rogov
- Institute of Biophysical and Center for Biomolecular Magnetic Resonance, Goethe University
- Flavie Strappazzon
- Department of Biology, University of Rome Tor Vergata
- Francesco Cecconi
- Department of Biology, University of Rome Tor Vergata
- DOI
- https://doi.org/10.1038/s41467-018-05722-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Mitophagy is crucial for mitochondrial quality control and maintenance of cellular homeostasis. Here the authors identify an E3 ubiquitin ligase, HUWE1, that collaborates with LC3-interacting protein AMBRA1 to induce mitochondrial clearance.
