BBA Advances (Jan 2022)

Ameliorative effect of fluvoxamine against colon carcinogenesis via COX-2 blockade with oxidative and metabolic stress reduction at the cellular, molecular and metabolic levels

  • Pranesh Kumar,
  • Mohit Kumar,
  • Anurag Kumar Gautam,
  • Archana Bharti Sonkar,
  • Abhishek Verma,
  • Amita Singh,
  • Raquibun Nisha,
  • Umesh Kumar,
  • Dinesh Kumar,
  • Tarun Mahata,
  • Bolay Bhattacharya,
  • Biswanath Maity,
  • Abhishek Pandeya,
  • Sunil Babu Gosipatala,
  • Sudipta Saha

Journal volume & issue
Vol. 2
p. 100046

Abstract

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Fluvoxamine's (FLX's) anticancer potential was investigated in pre-clinical research utilizing a DMH-induced colorectal cancer (CRC) rat model. qRT-PCR and immunoblotting validated the mechanistic investigation. The CRC condition was induced in response to COX-2 and IL-6, however, following FLX therapy, the condition returned to normal. FLX's anti-CRC potential may be attributable to COX-2 inhibition since this molecular activity was more apparent for COX-2 than IL-6. FLX repaired the altered metabolites linked to CRC rats, according to 1H-NMR analysis. FLX was shown to be similar to 5-FU in terms of tumor protection, which may be useful in future medication development.

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