Diastereo-selective synthesis of CF3-substituted epoxide via in situ generated trifluoroethylideneiodonium ylide

Abstract

The first example for the generation of 2,2,2-trifluoroethylidene ylide from corresponding iodonium salt is reported, which has been successfully applied in the epoxidation of aldehydes, achieving the corresponding trifluoromethylated epoxides in high yields and diastereo-selectivities.

Keywords

• Trifluoromethyl
• Epoxidation
• Epoxides
• Iodonium ylide
• Trifluoroethylidenation