SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

Jung-Hyun Kim; Kyuho Jeong; Jianfeng Li; James M. Murphy; Lana Vukadin; Joshua K. Stone; Alexander Richard; Johnny Tran; G. Yancey Gillespie; Erik K. Flemington; Robert W. Sobol; Ssang-Teak Steve Lim; Eun-Young Erin Ahn

doi:10.1038/s41467-021-25892-x

Nature Communications (Sep 2021)

SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

Jung-Hyun Kim,
Kyuho Jeong,
Jianfeng Li,
James M. Murphy,
Lana Vukadin,
Joshua K. Stone,
Alexander Richard,
Johnny Tran,
G. Yancey Gillespie,
Erik K. Flemington,
Robert W. Sobol,
Ssang-Teak Steve Lim,
Eun-Young Erin Ahn

Affiliations

Jung-Hyun Kim: Mitchell Cancer Institute, University of South Alabama
Kyuho Jeong: Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama
Jianfeng Li: Mitchell Cancer Institute, University of South Alabama
James M. Murphy: Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama
Lana Vukadin: Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham
Joshua K. Stone: Mitchell Cancer Institute, University of South Alabama
Alexander Richard: Mitchell Cancer Institute, University of South Alabama
Johnny Tran: Mitchell Cancer Institute, University of South Alabama
G. Yancey Gillespie: Department of Neurosurgery, University of Alabama at Birmingham
Erik K. Flemington: Department of Pathology, Tulane University School of Medicine, Tulane Cancer Center
Robert W. Sobol: Mitchell Cancer Institute, University of South Alabama
Ssang-Teak Steve Lim: Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama
Eun-Young Erin Ahn: Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham

DOI: https://doi.org/10.1038/s41467-021-25892-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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Splicing factor PTBP1 is reported to promote oncogenic functions in glioblastoma (GBM). Here the authors show splicing factor SON upregulates PTBP1 expression while supresses its paralog PTBP2 through alternative splicing and the inhibition of SON reduces GBM stemness and growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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