Nature Communications (Dec 2022)
Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations
- Caroline Le Dour,
- Maria Chatzifrangkeskou,
- Coline Macquart,
- Maria M. Magiera,
- Cécile Peccate,
- Charlène Jouve,
- Laura Virtanen,
- Tiina Heliö,
- Katriina Aalto-Setälä,
- Silvia Crasto,
- Bruno Cadot,
- Déborah Cardoso,
- Nathalie Mougenot,
- Daniel Adesse,
- Elisa Di Pasquale,
- Jean-Sébastien Hulot,
- Pekka Taimen,
- Carsten Janke,
- Antoine Muchir
Affiliations
- Caroline Le Dour
- Centre de recherche en Myologie, U974 SU-INSERM
- Maria Chatzifrangkeskou
- Centre de recherche en Myologie, U974 SU-INSERM
- Coline Macquart
- Centre de recherche en Myologie, U974 SU-INSERM
- Maria M. Magiera
- Institut Curie, Université PSL, CNRS UMR3348
- Cécile Peccate
- Centre de recherche en Myologie, U974 SU-INSERM
- Charlène Jouve
- Université de Paris, Paris Cardiovascular Research Center PARCC, INSERM
- Laura Virtanen
- Institute of Biomedicine and FICAN West Cancer Centre, University of Turku
- Tiina Heliö
- Heart and Lung Centre, Helsinki University Central Hospital, University of Helsinki
- Katriina Aalto-Setälä
- Faculty of Medicine and Health Technology and BioMediTech Institute, Tampere University
- Silvia Crasto
- Institute of Genetic and Biomedical Research (IRGB), UOS of Milan, National Research Council of Italy
- Bruno Cadot
- Centre de recherche en Myologie, U974 SU-INSERM
- Déborah Cardoso
- Centre de recherche en Myologie, U974 SU-INSERM
- Nathalie Mougenot
- Sorbonne Université, INSERM, UMS28 Phénotypage du petit animal
- Daniel Adesse
- Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Estrutural
- Elisa Di Pasquale
- Institute of Genetic and Biomedical Research (IRGB), UOS of Milan, National Research Council of Italy
- Jean-Sébastien Hulot
- Université de Paris, Paris Cardiovascular Research Center PARCC, INSERM
- Pekka Taimen
- Institute of Biomedicine and FICAN West Cancer Centre, University of Turku
- Carsten Janke
- Institut Curie, Université PSL, CNRS UMR3348
- Antoine Muchir
- Centre de recherche en Myologie, U974 SU-INSERM
- DOI
- https://doi.org/10.1038/s41467-022-35639-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Lamin A/C gene mutations cause dilated cardiomyopathy associated with cofilin-1 phosphorylation and actin destabilization. Here, the authors show that phosphorylated cofilin-1 blunts the MRTF-A/SRF axis, leading to decreased tubulin acetylation and altered cardiac structure and function.
