Revista do Colégio Brasileiro de Cirurgiões ()

Immunohistochemical expression of HER-2/NEU-CERBB-2 in patients with adenocarcinoma of the stomach

  • Fernando K Cirne-Lima,
  • Aline de Souza Rosa,
  • Jane M U Kulczynski,
  • Diego S Mattana,
  • Kizzy Corezolla,
  • Luis F Moreira

DOI
https://doi.org/10.1590/S0100-69912009000200007
Journal volume & issue
Vol. 36, no. 2
pp. 131 – 134

Abstract

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OBJECTIVES: To determine the prevalence of Her-2/Neu-cerbb-2 in the gastric mucosa of patients with gastric adenocarcinoma in a brazilian patient group. METHODS: The immunohistochemical expression of Her-2/Neu was studied in 37 formalin-fixed paraffin-embedded tissue sections. RESULTS: The immunohistochemical reaction produced by the anti-HER-2/Neu antibody was positive in two cases (5.4%). CONCLUSION: The low prevalence of Her-2/Neu observed in these southern brazilian cases is probably due to the great number of poorly differentiated cancers in this serie.

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