Frontiers in Cell and Developmental Biology (Dec 2020)
miR-429-3p/LPIN1 Axis Promotes Chicken Abdominal Fat Deposition via PPARγ Pathway
- Xiaohuan Chao,
- Xiaohuan Chao,
- Xiaohuan Chao,
- Lijin Guo,
- Lijin Guo,
- Lijin Guo,
- Qi Wang,
- Qi Wang,
- Qi Wang,
- Weiling Huang,
- Weiling Huang,
- Weiling Huang,
- Manqing Liu,
- Manqing Liu,
- Manqing Liu,
- Kang Luan,
- Kang Luan,
- Kang Luan,
- Jinqi Jiang,
- Jinqi Jiang,
- Jinqi Jiang,
- Shudai Lin,
- Shudai Lin,
- Shudai Lin,
- Qinghua Nie,
- Qinghua Nie,
- Qinghua Nie,
- Wen Luo,
- Wen Luo,
- Wen Luo,
- Xiquan Zhang,
- Xiquan Zhang,
- Xiquan Zhang,
- Qingbin Luo,
- Qingbin Luo,
- Qingbin Luo
Affiliations
- Xiaohuan Chao
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Xiaohuan Chao
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Xiaohuan Chao
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Lijin Guo
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Lijin Guo
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Lijin Guo
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Qi Wang
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Qi Wang
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Qi Wang
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Weiling Huang
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Weiling Huang
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Weiling Huang
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Manqing Liu
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Manqing Liu
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Manqing Liu
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Kang Luan
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Kang Luan
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Kang Luan
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Jinqi Jiang
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Jinqi Jiang
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Jinqi Jiang
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Shudai Lin
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Shudai Lin
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Shudai Lin
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Qinghua Nie
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Qinghua Nie
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Qinghua Nie
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Wen Luo
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Wen Luo
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Wen Luo
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Xiquan Zhang
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Xiquan Zhang
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Xiquan Zhang
- College of Animal Science, South China Agricultural University, Guangzhou, China
- Qingbin Luo
- Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China
- Qingbin Luo
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Qingbin Luo
- College of Animal Science, South China Agricultural University, Guangzhou, China
- DOI
- https://doi.org/10.3389/fcell.2020.595637
- Journal volume & issue
-
Vol. 8
Abstract
To explore the regulatory mechanism of abdominal fat deposition in broilers, 100-day-old Sanhuang chickens (n = 12) were divided into high-fat and low-fat groups, according to the abdominal fat ratio size. Total RNA isolated from the 12 abdominal fat tissues was used for miRNA and mRNA sequencing. Results of miRNA and mRNA sequencing revealed that miR-429-3p was highly expressed in high-fat chicken whereas LPIN1 expression was downregulated. Further, we determined that miR-429-3p promoted preadipocyte proliferation and differentiation, whereas LPIN1 exerted an opposite effect. Notably, we found that the miR-429-3p/LPIN1 axis facilitated PPARγ pathway activation, which is closely associated with the progression of adipogenesis. In conclusion, our results provide evidence that a novel miR-429-3p/LPIN1 axis is involved in the regulation of adipogenesis, which may have a guiding role in the improvement of breeding for abdominal fat traits in broiler chickens.
Keywords
- RNA-Seq
- miR-429-3p/LPIN1 axis
- preadipocyte proliferation
- preadipocyte differentiation
- PPARγ pathway abstract