Nature Communications (Oct 2017)
CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation
- Xuan Li,
- Xiao-Qi Wu,
- Rong Deng,
- Dan-Dan Li,
- Jun Tang,
- Wen-Dan Chen,
- Jing-Hong Chen,
- Jiao Ji,
- Lin Jiao,
- Shan Jiang,
- Fen Yang,
- Gong-Kan Feng,
- Ravichandran Senthilkumar,
- Fei Yue,
- Hai-Liang Zhang,
- Rui-Yan Wu,
- Yan Yu,
- Xue-Lian Xu,
- Jia Mai,
- Zhi-Ling Li,
- Xiao-Dan Peng,
- Yun Huang,
- Xiang Huang,
- Ning-Fang Ma,
- Qian Tao,
- Yi-Xin Zeng,
- Xiao-Feng Zhu
Affiliations
- Xuan Li
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Xiao-Qi Wu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Rong Deng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Dan-Dan Li
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Jun Tang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Wen-Dan Chen
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Jing-Hong Chen
- Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University
- Jiao Ji
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Lin Jiao
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Shan Jiang
- Department of Oncology, The First Affiliated Hospital, Chongqing Medical University
- Fen Yang
- Department of Biochemistry and Molecular Biology, Nanjing Medical University
- Gong-Kan Feng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Ravichandran Senthilkumar
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Fei Yue
- Institute of Biosciences and Technology, Texas A&M University Health Science Center
- Hai-Liang Zhang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Rui-Yan Wu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Yan Yu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Xue-Lian Xu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Jia Mai
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Zhi-Ling Li
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Xiao-Dan Peng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Yun Huang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Xiang Huang
- The School of Medicine, Jinan University
- Ning-Fang Ma
- Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Qian Tao
- Sir YK Pao Cancer Centre, Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Yi-Xin Zeng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- Xiao-Feng Zhu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-017-01272-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Neuroblastoma cell differentiation is regulated by Id proteins. Here, the authors show that CaMKII-mediated phosphorylation of Beclin 1 can activate K63-linked ubiquitination and autophagic degradation of Id proteins uncovering a role for autophagy in cell differentiation.
