EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

Julian C. Lui; Presley Garrison; Quang Nguyen; Michal Ad; Chithra Keembiyehetty; Weiping Chen; Youn Hee Jee; Ellie Landman; Ola Nilsson; Kevin M. Barnes; Jeffrey Baron

doi:10.1038/ncomms13685

Nature Communications (Nov 2016)

EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

Julian C. Lui,
Presley Garrison,
Quang Nguyen,
Michal Ad,
Chithra Keembiyehetty,
Weiping Chen,
Youn Hee Jee,
Ellie Landman,
Ola Nilsson,
Kevin M. Barnes,
Jeffrey Baron

Affiliations

Julian C. Lui: Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Presley Garrison: Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Quang Nguyen: Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Michal Ad: Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Chithra Keembiyehetty: Genomic Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Weiping Chen: Genomic Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Youn Hee Jee: Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Ellie Landman: Division of Pediatric Endocrinology. Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital
Ola Nilsson: Division of Pediatric Endocrinology. Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital
Kevin M. Barnes: Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Jeffrey Baron: Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health

DOI: https://doi.org/10.1038/ncomms13685
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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