One-day examination of triple nuclear medicine imaging and application in evaluating transarterial embolization

Nan Du; Guorong Jia; Wen Zhang; Qianqian Tong; Xudong Qu; Rong Liu; Danni Li; Zhiping Yan; Changjing Zuo; Xiao Li; Rou Li; Wei Zhang

Heliyon (May 2024)

One-day examination of triple nuclear medicine imaging and application in evaluating transarterial embolization

Nan Du,
Guorong Jia,
Wen Zhang,
Qianqian Tong,
Xudong Qu,
Rong Liu,
Danni Li,
Zhiping Yan,
Changjing Zuo,
Xiao Li,
Rou Li,
Wei Zhang

Affiliations

Nan Du: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Shanghai Institution of Medical Imaging, Shanghai, 200032, China; National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China
Guorong Jia: Department of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, 200433, China
Wen Zhang: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Shanghai Institution of Medical Imaging, Shanghai, 200032, China; National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China
Qianqian Tong: Department of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, 200433, China
Xudong Qu: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Shanghai Institution of Medical Imaging, Shanghai, 200032, China; National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China
Rong Liu: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Shanghai Institution of Medical Imaging, Shanghai, 200032, China; National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China
Danni Li: Department of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, 200433, China
Zhiping Yan: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Shanghai Institution of Medical Imaging, Shanghai, 200032, China; National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China
Changjing Zuo: Department of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, 200433, China
Xiao Li: Department of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, 200433, China; Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China; Corresponding author.
Rou Li: Department of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, 200433, China; Corresponding author.
Wei Zhang: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Shanghai Institution of Medical Imaging, Shanghai, 200032, China; National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China; Corresponding author. Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Journal volume & issue: Vol. 10, no. 9
p. e29597

Abstract

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A diagnosis based on multiple nuclear medicine imaging (NMI) was more comprehensive in approaching the nature of pathological changes. In this research, a method to realize triple NMIs within one day was developed based on the reasonable arrangements of 68Ga-RGD PET/CT specialized on neovascularization, 99mTc-HL-91 SPECT/CT specialized on hypoxia and 18F-FDG PET/CT specialized on tumor metabolism. Feasibility was verified in evaluating the therapeutic effects of transarterial embolization (TAE) performed on rabbit models with VX2 tumor. Radiation dosimetry was carried out to record the radiation exposure from multiple injections of radiopharmaceuticals. In results, the one-day examination of triple NMIs manifested the diversity of the postoperative histological changes, including the local neovascularization induced by embolization, hypoxic state of embolized tissues, and suppression of tumor metabolism. More importantly, radiation dosage from radiopharmaceuticals was limited below 5.70 ± 0.90 mSv. In conclusion, the strong timeliness and complementarity of one-day examination of triple nuclear medicine imaging made it clinically operative and worthy of popularizing. There was flexibility in combining distinct NMIs according to the clinical demands, so as to provide comprehensive information for diagnosis.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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