Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk

Lucas H. Ting; Shirin Feghhi; Nikita Taparia; Annie O. Smith; Ari Karchin; Esther Lim; Alex St. John; Xu Wang; Tessa Rue; Nathan J. White; Nathan J. Sniadecki

doi:10.1038/s41467-019-09150-9

Nature Communications (Mar 2019)

Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk

Lucas H. Ting,
Shirin Feghhi,
Nikita Taparia,
Annie O. Smith,
Ari Karchin,
Esther Lim,
Alex St. John,
Xu Wang,
Tessa Rue,
Nathan J. White,
Nathan J. Sniadecki

Affiliations

Lucas H. Ting: Mechanical Engineering, University of Washington
Shirin Feghhi: Mechanical Engineering, University of Washington
Nikita Taparia: Mechanical Engineering, University of Washington
Annie O. Smith: Mechanical Engineering, University of Washington
Ari Karchin: Mechanical Engineering, University of Washington
Esther Lim: Department of Emergency Medicine, University of Washington
Alex St. John: Department of Emergency Medicine, University of Washington
Xu Wang: Department of Emergency Medicine, University of Washington
Tessa Rue: Biostatistics, University of Washington
Nathan J. White: Mechanical Engineering, University of Washington
Nathan J. Sniadecki: Mechanical Engineering, University of Washington

DOI: https://doi.org/10.1038/s41467-019-09150-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

Platelet aggregates generate contractile forces that contribute to their cohesion and adhesion. Here, Ting et al. develop a microfluidic device to measure contractile forces generated by platelet aggregates, and find it can detect the response of platelets to pharmacological agents and predict bleeding risk in trauma patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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