Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs

Yingnan Liu; Zhenhua Xie; Yao Li; Yingying Song; Dongdong Di; Jingyi Liu; Lang Gong; Zongyan Chen; Jinxian Wu; Zhengqin Ye; Jianqi Liu; Wanqi Yu; Lu Lv; Qiuping Zhong; Chuanwen Tian; Qingqing Song; Heng Wang; Hongjun Chen

doi:10.1080/22221751.2022.2148560

Emerging Microbes and Infections (Dec 2023)

Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs

Yingnan Liu,
Zhenhua Xie,
Yao Li,
Yingying Song,
Dongdong Di,
Jingyi Liu,
Lang Gong,
Zongyan Chen,
Jinxian Wu,
Zhengqin Ye,
Jianqi Liu,
Wanqi Yu,
Lu Lv,
Qiuping Zhong,
Chuanwen Tian,
Qingqing Song,
Heng Wang,
Hongjun Chen

Affiliations

Yingnan Liu: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Zhenhua Xie: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Yao Li: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Yingying Song: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Dongdong Di: The Spirit Jinyu Biological Pharmaceutical Co. Ltd, Hohhot, People’s Republic of China
Jingyi Liu: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Lang Gong: South China Agricultural University, Guangdong, People’s Republic of China
Zongyan Chen: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Jinxian Wu: The Spirit Jinyu Biological Pharmaceutical Co. Ltd, Hohhot, People’s Republic of China
Zhengqin Ye: The Spirit Jinyu Biological Pharmaceutical Co. Ltd, Hohhot, People’s Republic of China
Jianqi Liu: The Spirit Jinyu Biological Pharmaceutical Co. Ltd, Hohhot, People’s Republic of China
Wanqi Yu: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Lu Lv: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Qiuping Zhong: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Chuanwen Tian: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China
Qingqing Song: The Spirit Jinyu Biological Pharmaceutical Co. Ltd, Hohhot, People’s Republic of China
Heng Wang: South China Agricultural University, Guangdong, People’s Republic of China
Hongjun Chen: Shanghai Veterinary Research Institute, CAAS, Shanghai, People’s Republic of China

DOI: https://doi.org/10.1080/22221751.2022.2148560
Journal volume & issue: Vol. 12, no. 1

Abstract

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ABSTRACTAfrican swine fever (ASF) is a highly contagious disease of domestic and wild pigs caused by the African swine fever virus (ASFV). The current research on ASF vaccines focuses on the development of naturally attenuated, isolated, or genetically engineered live viruses that have been demonstrated to produce reliable immunity. As a result, a genetically engineered virus containing five genes deletion was synthesized based on ASFV Chinese strain GZ201801, named ASFV-GZΔI177LΔCD2vΔMGF. The five-gene-deleted ASFV was safe and fully attenuated in pigs and provides reliable protection against the parental ASFV strain challenge. This indicates that the five-gene-deleted ASFV is a potential candidate for a live attenuated vaccine that could control the spread of ASFV.

Published in Emerging Microbes and Infections

ISSN: 2222-1751 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Science: Microbiology
Website: https://www.tandfonline.com/journals/temi

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